Breast Cancer Research and Treatment

, Volume 5, Issue 2, pp 201–205 | Cite as

Family history and bilateral primary breast cancer

  • M A Chaudary
  • R R Millis
  • R D Bulbrook
  • J L Hayward


The prevalence of a family history of breast cancer was established in 54 women with bilateral primary breast cancer and 208 women with unilateral disease. Women with bilateral disease had significantly greater prevalence of family history than women with unilateral breast cancer (P<0.01). Compared with the unilateral cancers, a significantly greater proportion of bilateral cancers had first degree affected relatives (P<0.05). Moreover the affected relatives of probands with bilateral disease showed a significantly higher prevalence of bilateral breast cancer compared with the relatives of women with unilateral disease (P = 0.04). The findings suggested that bilateral disease was a characteristic of familial breast cancer.


breast cancer bilateral disease family history 


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Copyright information

© Martinus Nijhoff Publishers 1985

Authors and Affiliations

  • M A Chaudary
    • 1
  • R R Millis
    • 1
  • R D Bulbrook
    • 2
  • J L Hayward
    • 1
  1. 1.Imperial Cancer Research Fund Breast Cancer UnitGuy's HospitalLondonUK
  2. 2.Department of Clinical EndocrinologyImperial Cancer Research FundLondonUK

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