Advertisement

Breast Cancer Research and Treatment

, Volume 5, Issue 2, pp 201–205 | Cite as

Family history and bilateral primary breast cancer

  • M A Chaudary
  • R R Millis
  • R D Bulbrook
  • J L Hayward
Report

Summary

The prevalence of a family history of breast cancer was established in 54 women with bilateral primary breast cancer and 208 women with unilateral disease. Women with bilateral disease had significantly greater prevalence of family history than women with unilateral breast cancer (P<0.01). Compared with the unilateral cancers, a significantly greater proportion of bilateral cancers had first degree affected relatives (P<0.05). Moreover the affected relatives of probands with bilateral disease showed a significantly higher prevalence of bilateral breast cancer compared with the relatives of women with unilateral disease (P = 0.04). The findings suggested that bilateral disease was a characteristic of familial breast cancer.

Keywords

breast cancer bilateral disease family history 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Broca P: Traité des Tumeurs, Vol. I. P. Asselin, Paris, 1866, p 149Google Scholar
  2. 2.
    Anderson DE: Some characteristics of familial breast cancer. Cancer 28:1500–1504, 1971PubMedGoogle Scholar
  3. 3.
    Anderson DE: Genetic study of breast cancer: identification of a high risk group. Cancer 34:1090–1097, 1974PubMedGoogle Scholar
  4. 4.
    Henderson BE, Powell D, Rosario I, Keys C, Hanisch R, Young M, Casagrande J, Gerkins V, Pike MC: An epidemiologic study of breast cancer. J Natl Cancer Inst 53:609–614, 1974PubMedGoogle Scholar
  5. 5.
    Morgan RW, Vakil DU, Chipman ML: Breast feeding, family history and breast disease. Am J Epidemiol 99:117–122, 1974PubMedGoogle Scholar
  6. 6.
    Thiessen EU: Concerning a familial association between breast cancer and both prostatic and uterine malignancies. Cancer 34:1102–1107, 1974PubMedGoogle Scholar
  7. 7.
    Harris RE, Lynch HT, Guirgis HA: Familial breast cancer: risk to the contralateral breast. J Natl Cancer Inst 60:955–960, 1978PubMedGoogle Scholar
  8. 8.
    Hubbard TB, Montgomery ALA: Non-simultaneous bilateral carcinoma of the breast. Surgery 34:706–723, 1953PubMedGoogle Scholar
  9. 9.
    Kilgore AR, Bell HG, Ahlquist RE: Cancer in the second breast. Am J Surgery 126:156–160, 1956Google Scholar
  10. 10.
    Finney GG Jr, Finney GG, Montague ALW, Stonesifer GL, Brown CC: Bilateral breast cancer, clinical and pathological review. Ann Surg 1975:635–642, 1972Google Scholar
  11. 11.
    Buls JG, Bennett RC, Chan DPS: Bilateral carcinoma of the breast. Aust NZ J Surg 46:336–340, 1976Google Scholar
  12. 12.
    Sakamoto G, Sugano H, Kasumi F: Bilateral breast cancer and familial aggregations. Prev Med 7:225–229, 1978PubMedGoogle Scholar
  13. 13.
    Hermann JB: Bilateral Mammary Carcinoma. Acta Unio Internationalis Contra Cancrum 11:433–489, 1955PubMedGoogle Scholar
  14. 14.
    Watanatittan S, Ram MD: Non-simultaneous bilateral breast carcinoma. Surgery 75:740–745, 1974PubMedGoogle Scholar
  15. 15.
    Adami H, Hansen J, Jung B, Rimsten A: Characteristics of familial breast cancer in Sweden: absence of relation to age and unilateral versus bilateral disease. Cancer 48:1688–1695, 1981PubMedGoogle Scholar
  16. 16.
    Bailey MJ, Royce C, Sloane JP, Ford HT, Powles T-J, Gazet J-C: Bilateral carcinoma of the breast. Br J Surg 67:514–516, 1980PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers 1985

Authors and Affiliations

  • M A Chaudary
    • 1
  • R R Millis
    • 1
  • R D Bulbrook
    • 2
  • J L Hayward
    • 1
  1. 1.Imperial Cancer Research Fund Breast Cancer UnitGuy's HospitalLondonUK
  2. 2.Department of Clinical EndocrinologyImperial Cancer Research FundLondonUK

Personalised recommendations