Summary
A review of over 2000 patients who had estrogen receptors (ER) assayed in the primary breast carcinoma identified 48 cases in whom a subsequent second primary breast carcinoma or concurrent or recurrent secondary tumour had been tested for ER status. The relationship between the ER in the two specimens was as follows: Of 14 concurrent primary and secondary breast carcinomas the ER concentration was the same in 11 cases; in 1 case it was significantly higher in the primary tumour, in 2 others the reverse was observed. There was no major discordance in ER status. In 14 sequential carcinomas (after an average disease free time of 21 months), 12 pairs had identical ER status. There was major discordance of ER status in 2 cases where the secondary tumours contained ER while the primary carcinoma did not. The ER concentrations in the primary and the secondary carcinomas were comparable in 8 cases, while 3 and 5 cases had significantly higher or lower concentrations respectively in the sequential secondary tumour. In 20 cases where breast cancer developed in the contralateral breast (after an average disease-free interval of 27.7 months), essential concordance of ER status was observed in 15 of 20 sequential carcinomas. In 5 patients the first carcinoma was ER − and the second ER +; in one additional patient the first carcinoma was ER± and the second ER −. The ER concentrations differed significantly in 14 of the 20 bilateral carcinomas. The literature on estrogen receptor variation in breast carcinoma was reviewed.
References
Hull DF, Clark GM, Osborne CK, Chamness GC, Knight WA, McGuire WL: Multiple estrogen receptor assays in human breast cancer. Cancer Res 43:413–416, 1983
Holdaway IM, Bowditch JV: Variation in receptor status between primary and metastatic breast cancer. Cancer 52:479–485, 1983
Harland RNL, Barnes DM, Howell A, Ribeiro GG, Taylor J, Sellwood RA: Variation of receptor status in cancer of the breast. Br J Cancer 47:511–515, 1983
Bennett RC, Mercer RJ, Tat Hean Lie: Multiple or sequential oestrogen receptor assays in breast cancer. Aust N Z J Surg 53:231–236, 1983
Koenders AJ, Geurts-Moespot J, Kho KH, Benraad ThJ: Estradiol and progesterone receptor activities in stored lyophilized target tissue. J Steroid Biochem 9:947–950, 1978
Hähnel R, Twaddle E: Estimation of the association constant of the estrogen receptor complex in human breast cancer. Cancer Res 33:559–566, 1973
Rosenthal HE: A graphic method for the determination and presentation of binding parameters in a complex system. Anal Biochem 20:525–532, 1967
Brennan MJ, Donegan WL, Appleby DE: The variability of estrogen receptors in metastatic breast cancer. Am J Surg 137:260–262, 1979.
Fernandez D, Alaghband-Zadeh J, Sauven P, Burn JI: Variability of oestrogen and progesterone receptor status between primary breast cancer and nodal metastases: Preliminary communication. J Royal Soc Med 75:719–722, 1982.
Görlich M, Heise E: Öestradiolrezeptoren in Relation zu klinischen Parametern von Mammakarzinompatientinnen. Arch Geschwultsforsch 51:631–636, 1981
Hawkins RA, Black R, Steele RJC, Dixon JMJ, Forrest APM: Oestrogen receptor concentration in primary breast cancer and axillary node metastases. Breast Cancer Res Treat 1:245–251, 1981
Hoehn JL, Plotka ED, Dickson KB: Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast. Ann Surg 190:69–71, 1979
Hughes JM, Halley JBW, Irving MG: Oestrogen receptor protein in breast cancer: A local study. Pathol 11:181–190, 1979
Kiang DT, Kennedy BJ: Factors affecting estrogen receptors in breast cancer. Cancer 40:1571–1576, 1977
Klinga K, Kaufmann M, Runnebaum B, Kubli F: Distribution of estrogen and progesterone receptors on primary tumor and lymph nodes in individual patients with breast cancer. Oncol 39:337–339, 1982
Leclercq G, Heuson JC, Deboel MC, Mattheiem WH: Oestrogen receptors in breast cancer: A changing concept. Brit Med J 1:185–189, 1975
Meyer JS, Stevens SC, White WL, Hixon B: Estrogen receptor assay of carcinomas of the breast by a simplified dextran charcoal method. Am J Clin Pathol 70:655–664, 1978
Nomura Y: Estrogen receptor in breast cancer of the Japanese. Gann 67:703–711, 1976
Rosen PP, Menendez-Botet CJ, Urban JA, Fracchia A, Schwartz MK: Estrogen receptor protein in multiple tumor specimens from individual patients with breast cancer. Cancer 39:2194–2200, 1977
Spaeren U, Olsnes S, Brennhood I, Efskind J, Pihl A: Content of estrogen receptors in human breast cancers. Eur J Cancer 9:353–357, 1973
Straus MJ, Moran R, Muller RE, Wotiz HH: Estrogen receptor heterogeneity and the relationship between estrogen receptor and the tritiated thymidine labeling index in human breast cancer. Oncol 39:197–200, 1982
Terenius L, Johansson H, Rimsten A, Thorén L: Malignant and benign human mammary disease: Estrogen binding in relation to clinical data. Cancer 33:1364–1368, 1974
Webster DJT, Bronn DG, Minton JP: Estrogen receptor levels in multiple biopsies from patients with breast cancer. Am J Surg 136:337–338, 1978
Izuo M, Iino Y, Takikawa H: Inter-site variation of estrogen receptors in human breast cancers. Jap J Clin Oncol 12:43–38, 1982.
Tilley WD, Keightley DD, Cant ELM: Inter-site variation of oestrogen receptors in human breast cancers. Br J Cancer 38:544–546, 1978
DeSombre ER, Jensen EV: Estrophilin assays in breast cancer: Quantitative features and application to the mastectomy specimen. Cancer 46:2783–2788, 1980
Block GE, Jensen EV, Polley TZ: The prediction of hormonal dependency of mammary cancer. Ann Surg 182:342–351, 1975
Paridaens R, Sylvester RJ, Ferrazzi E, Legros N, Leclercq G, Heuson JC: Clinical significance of the quantitative assessment of estrogen receptors in advanced breast cancer. Cancer 46:2889–2895, 1980
Campbell FC, Elston CW, Blamey RW, Morris AH, Nicholson RI, Griffiths K, Haybittle JL: Quantitative oestradiol receptor values in primary breast cancer and response of metastases to endocrine therapy. Lancet ii:1317–1319, 1981
Peetz ME, Nunley DL, Moseley HS, Keenan EJ, Davenport CE, Fletcher WS: Multiple, simultaneous and sequential estrogen receptor values in patients with breast cancer. Am J Surg 143:591–594, 1982
Koenders A, Beex L, Smalls A, Kloppenborg P, Benraad Th: Oestradiol and progesterone receptors in multiple tumour specimens from patients with breast cancer. Neth J Med 23:62–67, 1980
Kiang DT, Kennedy BJ, Snover DC: Biological and histological characteristics of simultaneous bilateral breast cancer. Lancet ii:1105–1108, 1980
Hähnel R and Twaddle E: Estrogen receptors in human breast cancer 1. Methodology and characterization of receptors. Steroids 18:653–680, 1971
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Hähnel, R., Twaddle, E. The relationship between estrogen receptors in primary and secondary breast carcinomas and in sequential primary breast carcinomas. Breast Cancer Res Tr 5, 155–163 (1985). https://doi.org/10.1007/BF01805989
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DOI: https://doi.org/10.1007/BF01805989