Summary
Changes in tumor cell proliferation and chemosensitivity after partial (up to 3/4) surgical resection were studied in C3H/HeJ mammary tumors, In all studies surgical cytoreduction stimulated tumor cell proliferation in the residual tumor, as evidenced by increases in the3H-TdR labelling index between 24 and 72 hrs after surgery. The time of maximal proliferative activity was directly related to the amount of tumor removed. In spontaneous mammary tumors, proliferative recovery after 1/2 resection could be delayed by giving dexamethasone 24 hrs after resection. The regrowth delay after surgery and various combinations of dexamethasone, vincristine, 5-FU, and cyclophosphamide, was used to assess the significance of the kinetic changes in the residual tumor for the design of adjuvant therapeutic strategies.
The results indicated that the chemosensitivity of C3H/HeJ mammary tumors was substantially increased after surgical cytoreduction, and that these post-surgical changes were directly correlated with changes in tumor cell proliferative activity.
References
Braunschweiger PG, Schiffer LM: Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in ‘spontaneous’ and ‘transplantable’ mammary tumors. Cancer Treat Rep 62: 727–736, 1978.
Braunschweiger PG, Schiffer LM: Effect of adriamycin on the cell kinetics of 13762 rat mammary tumors and implications for therapy. Cancer Treat Rep 64: 293–300, 1980.
Braunschweiger PG, Schiffer LM: Cell kinetic-directed sequential chemotherapy with cyclophosphamide and adriamycin in T1699 mammary tumors. Cancer Res 40: 737–743, 1980.
Braunschweiger PG, Schenken LL, Schiffer LM: The cytokinetic basis for the design of efficacious radiotherapy protocols. Int J Radiat Oncol Biol Phys 5: 37–47, 1979.
Braunschweiger PG, Schenken LL, Schiffer LM: Kinetically directed combination therapy with adriamycin and X-irradiation in a mammary tumor model. Int J Rad Oncol Biol Phys 7: 747–753, 1981.
Looney WB, Hopkins HA, Grover WH, Macleod MS, Ritenour ER, Hobson AS: Solid tumor models for the assessment of different treatment modalities, XIII. Comparison of response and recovery of host and solid tumor to cyclophosphamide. Cancer 45: 2793–2798, 1980.
Lala PK: Influence of local environment on the growth parameters of the Ehrlich ascites tumor. Eur J Cancer 8: 197–204, 1972.
Simpson-Herron L, Sanford AH, Holmquist JP: Effects of surgery on the cell kinetics of residual tumor. Cancer Treat Rep 60: 1749–1760, 1976.
Simpson-Herron L, Springer TA, Sanford AH, Holmquist JP: Kinetics and metastases in experimental tumors.In SB Day, WPL Myers, P Stanley, S Garratini, and MG Lewis (eds). Cancer Invasion and Metastasis: Biological Mechanisms and Therapy. Raven Press, New York, 1977, pp 117–133.
Gunduz N, Fisher B, Safer EA: Effect of surgical removal on the growth and kinetics of residual tumor. Cancer Res 39: 197–204, 1972.
Braunschweiger PG, Schiffer LM: The antiproliferative effects of corticosteroids in C3H/HeJ mammary tumors and implications for sequential combination chemotherapy. Cancer Res 41: 3324–3330, 1981.
Braunschweiger PG, Poulakos L, Schiffer LM: Cell kinetics in vivo and in vitro for C3H/HeJ spontaneous mammary tumors. J Natl Cancer Inst 59: 1197–1204, 1977.
Braunschweiger PG, Poulakos L, Schiffer LM: In vitro labeling and gold activation autoradiography for determination of labeling index and DNA synthesis times of solid tumors. Cancer Res 36: 1748–1753, 1976.
Desser-Wiest L: Autosynchronization of rat liver cells with endogenous corticosterone after partial hepatectomy. Cell Tissue Kinet 8: 1–9, 1975.
Braunschweiger PG, Stragand JJ, Schiffer LM: Effect of methylprednisolone on cell proliferation in C3H/HeJ spontaneous mammary tumors. Cancer Res 38: 4510–4514, 1978.
Reiter RJ, McCreight CE: Influence of the adrenal glands on DNA synthesis in normal and compensating kidneys. J Exp Zool 160: 1749–1760, 1976.
Braunschweiger PG, Ting HL, Schiffer LM: Receptor dependent antiproliferative effects of corticosteroids in RIF tumors and implications for sequential therapy. Cancer Res (in press)
Braunschweiger PG, Schiffer LM: Biochemical and cytokinetic studies on corticosteroid sensitivity of Lewis lung tumors (Abstract). Proc AACR 22: 228, 1981.
Braunschweiger PG, Schiffer LM: Effect of methylprednisolone on the cell kinetic response of C3H/HeJ mammary tumors to cyclophosphamide and adriamycin. Cancer Res 39: 3812–3815, 1979.
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Braunschweiger, P.G., Schiffer, L.M. & Betancourt, S. Tumor cell proliferation and sequential chemotherapy after partial tumor resection in C3H/HeJ mammary tumors. Breast Cancer Res Tr 2, 323–329 (1982). https://doi.org/10.1007/BF01805873
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DOI: https://doi.org/10.1007/BF01805873