Abstract
This paper reports biochemical studies in a pregnant xanthinuric female (McKusick 27830) and compares the results with findings in three other xanthinurics studied by us, including a previously unreported female who had a nephrectomy for xanthine stones.
The findings of raised levels of uric acid in plasma and urine at presentation in the third trimester of pregnancy, and the subsequent fall to almost undetectable levels 6 weeks post-partum, is regarded as evidence of the extent of fetal uric acid production and clearance by the maternal circulation.
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Chalmers, R. A., Parker, R., Simmonds, H. A., Snedden, W. and Watts, R. W. E. The conversion of 4-hydroxypyrazolo (3,4-d) pyrimidine (allopurinol) to 4,6-dihydroxypyrazolopyrimidine (oxipurinol)in vivo in the absence of xanthineoxygen oxidoreductase.Biochem. J. 112 (1969) 421–427
Dunlop, W. and Davison, J. M. The effect of normal pregnancy upon the renal handling of uric acid.Br. J. Obs. Gynaecol. 84 (1977) 13–21
Egwuatu, V. E. Plasma urate, urea and creatinine levels during pregnancy and after the puerperium in normal primigravid Nigerians.Br. J. Obs. Gynaecol. 90 (1983) 21–25
Harkness, R. A., Coade, S. B., Walton, K. R. and Wright, D. Xanthine oxidase deficiency and ‘Dalmation’ hypouncaemia: effect of exercise and incidence.J. Inher. Metab. Dis. 6 (1983) 114–121
Holmes, E. W. and Wyngaarden, J. B. InThe Metabolic Basis of Inherited Disease, 5th edn., McGraw-Hill, New York, 1983, pp. 1192–1202
Sahota, A., Simmonds, H. A. and Payne, R. H. Separation of urinary purines by isotachophoresis: usefulness in screening for inborn errors of purine and pyrimidine metabolism.J. Pharmacol. Methods 2 (1979) 263–278
Simmonds, H. A. Urinary excretion of purines, pyrimidines and pyrazolopyrimidines in patients treated with allopurinol or oxipurinol.Clim. Chim. Acta 23 (1969) 353–364
Simmonds, H. A., Levin, B. and Cameron, J. S. Variations in allopurinol metabolism by xanthinuric subjects.Clin. Sci. Molec. Med. 47 (1974) 173–178
Watts, R. W. E., Engleman, K., Klinenberg, J. R., Seegmiller, J. E. and Sjoerdsma, A. The enzyme defect in a case of xanthinuria.Biochem. J. 90 (1964) 4p
Webster, D. R., Simmonds, H. A., Barry, D. M. J. and Becroft, D. M. O. Pyrimidine and purine metabolites in ornithine transcarbamoylase deficiency.J. Inher. Metab. Dis. 4 (1981) 27–31
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Simmonds, H.A., Stutchbury, J.H., Webster, D.R. et al. Pregnancy in xanthinuria: Demonstration of fetal uric acid production?. J Inherit Metab Dis 7, 77–79 (1984). https://doi.org/10.1007/BF01805810
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DOI: https://doi.org/10.1007/BF01805810