Abstract
Multiple sulphatase deficiency was studied in 3 siblings — one pair of monozygotic twins and their sister. The children's psychomotor development was arrested at the age of 18 to 24 months, and the hypotonic syndrome combined with signs of spasticity appeared. There was marked hepatosplenomegaly, conspicuously dry scaly skin with the decortication syndrome developing and persisting in the presence of pronounced cachexia. Also present were numerous X-ray abnormalities, metachromatically staining granules in the urine, and Alder-Reilly's bodies in the blood leukocytes and in specimens of bone marrow. Liver, skin and muscle biopsies performed simultaneously revealed accumulations of water-soluble mucopolysaccharides and deposits of sulphatides in the two twins. Enzyme assays demonstrated arylsulphatase A and B deficiency. The diagnosis was subsequently confirmed at all the three siblings' postmortem examinations.
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Austin, J. H. Recent studies in the metachromatic and globoid body forms of diffuse sclerosis. In Folch-Pi and Bauer, H. (eds.)Brain Lipids and Lipoproteins, and Leucodystrophies, Elsevier, Amsterdam, 1963, p. 120
Austin, J. H. Mental retardation, metachromatic leucodystrophy (sulfatide lipidosis, metachromatic leucoencephalopathy). In Carter, C. H. (ed.)Medical Aspects of Mental Retardation, Charles C. Thomas, Springfield, 1965, p. 768
Elleder, M. Prolonged methanol fixation of soluble mucosubstances in mucopolysaccharidosis.Histochemistry 41 (1976) 161–165
Elleder, M. and Lojda, Z. Studies in lipid histochemistry. X. lipids in paraffin sections.Histochemie 34 (1973) 143–156
Moser, H. W. MLD variant with multiple sulfatase deficiencies. In Stanbury, J. B., Wyngaarden, J. B. and Frederickson, D. S. (eds.)Metabolic Basis of Inherited Disease, McGraw-Hill, 1972, pp. 705–708
Moser, H. W. Metachromatic leucodystrophy and multiple sulfatase deficiency. In Vinken, P. J. and Bruyn, G. W. (eds.)Handbook of Clinical Neurology, North-Holland, Amsterdam, 1981, 42/I, pp. 491–495
Murphy, J. V., Wolfe, H. J., Balazs, E. A. and Moser, H. W. A patient with deficiency of arylsulfatases A,B,C and steroid sulfatases, associated with storage of sulfatide, cholesterol-sulfate and glycosaminoglycans. In Bernsohn, J. and Grossman, H. J. (eds.)Lipid Storage Diseases: Enzymatic Defects and Clinical Implications, Academic Press, New York, 1971, pp. 67–110
Suzuki, K. Enzymatic diagnosis of sphingolipidoses. In Colowick, S. P. and Kaplan, N. O. (eds.)Methods of Enzymology, Vol. I, Academic Press, New York, 1978, pp. 472–475
Thieffry, S., Lyon, G. and Maroteaux, P. Leucodystrophic métachromatique (sulfatidose) mucopolysaccharidose associéz chez un méme malade.Rev. Neurol. (Paris), 114 (1966) 193
Thieffry, S., Lyon, G. and Maroteaux, P. Metabolic encephalopathy associating mucopolysaccharidosis and sulfatidosis.Arch. Franc. Pediat. 24 (1967) 425
Tichý, J. Vergleichende Untersuchungen der Lipide im Blut und Liquor cerebrospinalis.Z. Ges Inn. Med. (Leipzig), 27 (1072) (1972) 21–25
Tichý, J. Inborn errors of lipid metabolism. In Hyánek, J.et al. (eds.)Clinical and Biochemical Aspects on Inborn Metabolic Errors (Czech) Avicenum, Prague, 1979, pp. 185–200
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Nevšímalová, S., Elleder, M., Šmíd, F. et al. Multiple sulphatase deficiency in homozygotic twins. J Inherit Metab Dis 7, 38–40 (1984). https://doi.org/10.1007/BF01805620
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DOI: https://doi.org/10.1007/BF01805620