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Journal of Inherited Metabolic Disease

, Volume 12, Issue 1, pp 89–93 | Cite as

Persistent hyperkalaemia in vitamin B12 unresponsive methylmalonic acidaemia

  • J. Morita
  • Y. Ito
  • M. Yoshino
  • Y. Koga
  • S. Yano
  • I. Yoshida
  • F. Yamashita
Article

Summary

Persistent hyperkalaemia was found in a patient with vitamin B12 unresponsive methylmalonic acidaemia associated with hyperuricaemia. At 3 years and 8 months of age, a serum potassium level of 6.8 mmol L−1 was found when blood gas measurement was normal. One year later azotaemia was noted. At the age of 5 years, renal function studies disclosed hyperaldosteronism, decreased creatinine clearance, reduction of the reabsorption of sodium at distal diluting segments and inadequate concentration of urine at the collecting ducts. The reduction of the reabsorption of sodium, which may have resulted in decreased potassium excretion, and the decrease in glomerular filtration rate, together with the superimposed excess intake of potassium, appeared to be responsible for the hyperkalaemia. Dietary potassium restriction was effective in suppressing the hyperkalaemia.

Keywords

Glomerular Filtration Rate Hyperaldosteronism Glomerular Filtration Creatinine Clearance Function Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© SSIEM and Kluwer Academic Publishers 1989

Authors and Affiliations

  • J. Morita
    • 1
  • Y. Ito
    • 1
  • M. Yoshino
    • 1
  • Y. Koga
    • 1
  • S. Yano
    • 1
  • I. Yoshida
    • 1
  • F. Yamashita
    • 1
  1. 1.Department of Pediatrics and Child HealthKurume University, School of MedicineKurumeJapan

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