, Volume 35, Issue 1, pp 109–126 | Cite as

Analysis of chromosome 4 inDrosophila melanogaster. I. Spontaneous and X-ray-induced lethals

  • B. Hochman
  • H. Gloor
  • M. M. Green


An analysis of 17 spontaneous and 37 X-ray-induced lethal mutations on the fourth chromosome ofDrosophila melanogaster has revealed a minimum of 22 loci on this microchromosome capable of mutating to lethality. A few of these loci had been identified earlier by their “visible” alleles but 16 are new discoveries. Seven of the 22 lethal loci are situated within that proximal section of the right arm of chromosome 4 delimited by theMinute-4 deficiency.

Genetic tests indicate that two translocations and five deletions are included among the lethals of X-ray origin. No chromosomal aberrations were found among the spontaneous mutants. Allelism was encountered both within and between lethals from the two groups.

Three independent estimates of the total number of lethal loci to be expected on this small autosome are presented. These appraisals are based on (1) the size of theMinute-4 deficiency, (2) the number of bands in salivary chromosome 4, and (3) the frequency of recurrence among the lethals. Considering the uncertainties inherent in each determination, the three estimates (34, 35 and 38) show remarkably good agreement.


Genetic Test Chromosomal Aberration Spontaneous Mutant Independent Estimate Lethal Mutation 
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Copyright information

© Martinus Nijhoff 1964

Authors and Affiliations

  • B. Hochman
    • 1
    • 2
    • 3
  • H. Gloor
    • 1
    • 2
    • 3
  • M. M. Green
    • 1
    • 2
    • 3
  1. 1.Department of Zoology and EntomologyThe University of TennesseeKnoxvilleU.S.A.
  2. 2.Genetisch Laboratorium der RijksuniversiteitLeidenThe Netherlands
  3. 3.Department of GeneticsUniversity of CaliforniaDavisU.S.A.

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