Breast Cancer Research and Treatment

, Volume 38, Issue 1, pp 3–9 | Cite as

Recombinant immunotoxins

  • Ira Pastan
  • Lee H. Pai
  • Ulrich Brinkmann
  • David FitzGerald


Pseudomonas exotoxin has been genetically modified so that it targets cancer cells. This was accomplished by deleting its cell binding domain and replacing it with Fv fragments of antibodies that react with breast, colon, and other cancers. Several recombinant immunotoxins are now in clinical trials.

Key words

breast cancer cancer treatment colon cancer Pseudomonas exotoxin 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Ira Pastan
    • 1
  • Lee H. Pai
    • 1
  • Ulrich Brinkmann
    • 1
  • David FitzGerald
    • 1
  1. 1.Laboratory of Molecular Biology, Division of Cancer Biology, Diagnosis and CentersNational Cancer Institute, National Institutes of HealthBethesdaUSA

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