Relationship between mammographic pattern and estrogen receptor content in breast cancer
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The mammographic pattern and its relationship to the estrogen receptor (ER) content was studied in 184 breast cancers. The tumors were divided into five radiographic subgroups: mass with spicules (A), diffuse (B), clusters of calcifications without a mass (C), circumscribed (D), and not visible at mammography (E). The ER content of tumors belonging to group A was higher than that of the other subgroups in both pre- and postmenopausal women. 121 tumors belonged to group A, of which 80% were ductal cancers. The tumors in groups B and C had very low ER values and those of groups D and E had intermediate values.
The likelihood of finding a high estrogen receptor content of a tumor is thus greater when the tumor radiographically is seen as a mass with spicules than when seen as an increased attenuation or as only clusters of calcifications. It is suggested that patients with tumors belonging to group A should have a more favorable prognosis than patients with tumors belonging to groups B and C.
Keywordsbreast cancer estrogen receptor mammographic pattern
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- 3.Franzén S, Zajicek J: Aspiration biopsy in diagnosis of palpable lesions of the breast. Acta Radiol 7: 241–260, 1968Google Scholar
- 5.Wolfe JN: Analysis of 462 breast carcinomas. Am J Roentgenol 121: 846–853, 1974Google Scholar
- 6.Bjurstam NG: Radiography of the female breast and axilla. Acta Radiol Suppl 357, 1978Google Scholar
- 8.Armitage P: Statistical Methods in Medical Research. Blackwell, Oxford, 1971Google Scholar
- 9.SAS Users Guide. SAS Institute, Cary NC, USA 1979Google Scholar
- 10.Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De Lena M, Gallus G, Greco M, Luini A, Marubini E, Muscolino G, Rolke F, Salvadori B, Zecchini A, Zucali R: Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 305: 6–11, 1981PubMedGoogle Scholar
- 13.Auer GU, Caspersson TO, Gustafsson SA, Humla SA, Ljung BM, Nordenskjöld BA, Silfverswärd C, Wallgren AS: Relationship between nuclear DNA distribution and estrogen receptors in human mammary carcinomas. Anal Quant Cytol 4: 280–284, 1980.Google Scholar
- 17.Linell F, Ljungberg O, Andersson I: Breast carcinoma. Aspects of early stages, progression and related problems. Acta Pathol Microbiol Scand Suppl 272, 1980.Google Scholar