Disaggregation of polyribosomes and depletion of amino acids in brain tissue after a single injection of amino acid in young rats

  • Kikumaro Aoki
Short Communication


  1. Aoki, K. and Siegel, F. L. Hyperphenylalaninemia: Disaggregation of brain polyribosomes in young rats.Science 168 (1970) 129–130Google Scholar
  2. Appel, S. H. Inhibition of brain protein synthesis: an approach to biochemical basis of neurological dysfunction in the aminoacidurias.Trans N.Y. Acad. Sci. 29 (1966) 63–70Google Scholar
  3. McKean, C. M., Boggs, D. E. and Peterson, N. A. The influence of high phenylalanine and tyrosine on the concentration of essential amino acids in brain.J. Neurochem. 15 (1968) 235–241Google Scholar
  4. Oates, J. A., Nirenberg, D. Z., Jepson, J. B., Sjoerdsma, A. and Udenfriend, S. Conversion of phenylalanine to phenylethylamine in patients with phenylketonuria.Proc. Soc. Exp. Biol. Med. 112 (1963) 1078–1081Google Scholar
  5. Siegel, F. L., Aoki, K. and Colwell, R. E. Polyribosome disaggregation and cell-free protein synthesis in preparation from cerebral cortex of hyperphenylalaninemic rats.J. Neurochem. 18 (1971) 537–547Google Scholar

Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • Kikumaro Aoki
    • 1
  1. 1.Research Development DepartmentAiiku Maternal and Child Health CenterTokyoJapan

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