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Azelaic and pimelic acids: Metabolic intermediates or artefacts?

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Journal of Inherited Metabolic Disease

Summary

Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.

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Author notes

  1. M. J. Bennett

    Present address: Kimberly M. Courtwright and Joseph W. Summers Metabolic Disease Center, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA

Authors and Affiliations

  1. Department of Pediatrics, The Children's Hospital of Philadelphia, USA

    M. J. Bennett, M. C. Ragni & D. E. Hale

  2. Philadelphia Medical Examiner's Office, USA

    I. Hood

Authors
  1. M. J. Bennett
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  2. M. C. Ragni
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  3. I. Hood
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  4. D. E. Hale
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Bennett, M.J., Ragni, M.C., Hood, I. et al. Azelaic and pimelic acids: Metabolic intermediates or artefacts?. J Inherit Metab Dis 15, 220–223 (1992). https://doi.org/10.1007/BF01799635

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  • DOI: https://doi.org/10.1007/BF01799635

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