Journal of Inherited Metabolic Disease

, Volume 13, Issue 4, pp 617–626 | Cite as

Transport of amino acids by the human placenta: Predicted effects thereon of maternal hyperphenylalaninaemia

  • Y. Kudo
  • C. A. R. Boyd
Maternal PKU Workshop

Summary

Brush border and basal plasma membrane vesicles prepared from normal term human placental syncytiotrophoblast have been used to study amino acid transport. Such studies are reviewed and novel results presented which confirm that saturation of placental transport by phenylalanine is unlikely to limit delivery of this amino acid to the fetus even with grossly raised maternal concentrations. Such raised maternal levels of phenylalanine are, however, likely to severely embarrass the delivery to the fetus across the placental brush border membrane ofl-tyrosine and, to a lesser extent, ofl-tryptophan. Reasons for thinking that this may be relevant to the fetal damage found in maternal PKU are discussed.

Keywords

Phenylalanine Membrane Vesicle Brush Border Amino Acid Transport Human Placenta 

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References

  1. Boyd, C. A. R. and Lund, E. K.l-proline transport by brush border membrane veislces prepared from human placenta.J. Physiol. 315 (1981) 9–19Google Scholar
  2. Christensen, H. N.Biological Transport, 2nd edn., W. A. Benjamin, Reading, Mass., 1975Google Scholar
  3. Eaton, B. M., Mann, G. E. and Yudilevich, D. L. Transport specificity for neutral and basic amino acids at maternal and fetal interfaces of the guinea-pig placenta.J. Physiol. 328 (1982) 245–258Google Scholar
  4. Ganapathy, M. E., Leibach, F. H., Mahesh, V. B., Howard, J. C., Devoe, L. D. and Ganapathy, V. Characterization of tryptophan transport in human placental brush-border membrane vesicles.Biochem. J. 238 (1986) 201–208Google Scholar
  5. Hoeltzli, S. D. and Smith, C. H. Alanine transport systems in isolated basal plasma membrane of human placenta.Am. J. Physiol. 256 (1989) C630-C637Google Scholar
  6. Huether, G. The depletion of tryptophan and serotonin in the brain of developing hyperphenyl-alaninemic rats is abolished by the additional administration of lysine.Neurochem. Res. 11 (1986) 1663–1668Google Scholar
  7. Karl, P. I., Tkaczevski, H. and Fisher, S. E. Characteristics of histidine uptake by human placental microvillous membrane vesicles.Pediatr. Res. 25 (1989) 19–26Google Scholar
  8. Kirby, M. L., Turnage, K. L. and Hays, B. M. Characterization of conotruncal malformations following ablation of ‘cardiac’ neural crest.Anat. Rec. 213 (1985) 87–93Google Scholar
  9. Kudo, Y. and Boyd, C. A. R. Characterization of amino acid transport systems in human placental basal membrane vesicles.Biochim. Biophys. Acta 1021 (1990) 169–174Google Scholar
  10. Kudo, Y., Yamada, K., Fujiwara, A. and Kawasaki, T. Characterization of amino acid transport systems in human placental brush-border membrane vesicles.Biochim. Biophys. Acta 904 (1987) 309–318Google Scholar
  11. Lenke, R. R., Koch, R., Fishler, K. and Platt, L. D. Tyrosine supplementation during pregnancy in a woman with classical phenylketonuria.J. Reprod. Med. 28 (1983) 411–141Google Scholar
  12. Levy, H. Maternal phenylketonuria.Enzyme 38 (1987) 312–320Google Scholar
  13. Levy, H. L., Lenke, R. R. and Koch, R. Lack of fetal effect on blood phenylalanine concentration in maternal phenylketonuria.J. Pediatr. 104 (1984) 245–247Google Scholar
  14. Pratt, R. M., Goulding, E. H. and Abbott, B. D. Retinoic acid inhibits migration of cranial neural crest cells in the cultured mouse embryo.J. Craniofacial Gen. Dev. Biol. 7 (1987) 205–217Google Scholar
  15. Stulc, J. C. Placental paracellular transport.Placenta 10 (1989) 113–119Google Scholar
  16. Suyama, I., Tani, M., Matsumura, M., Isshiki, G., Okano, Y., Oura, T. and Nishimura, K. Fetal heart malformations in experimental hyperphenylalaninemia in pregnant rats.Congen. Anom. 29 (1989) 15–29Google Scholar
  17. Yudilevich, D. L. and Boyd, C. A. R.Amino Acid Transport in Animal Cells, Manchester University Press, Manchester, 1987Google Scholar
  18. Yudilevich, D. L. and Sweiry, J. H. Transport of amino acids in the placenta.Biochim. Biophys. Acta 822 (1985) 169–201Google Scholar

Copyright information

© SSIEM and Kluwer Academic Publishers 1990

Authors and Affiliations

  • Y. Kudo
    • 1
  • C. A. R. Boyd
    • 1
  1. 1.Department of Human AnatomyOxford UniversityOxfordUK

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