Summary
To determine the effect of aging on the diastolic function of the left ventricle (LV) echo examination was performed in 115 subjects (47 women, 68 men) without any evidence of organic heart disease (2D and Doppler echo; exercise electrocardiography) aged 21 to 72 (mean ± SD: 41 ± 14) years. Transmitral flow with the characteristic early and late diastolic E-wave (E) and A-wave (A) was derived by pulsed Doppler ultrasound, whereas isovolumetric relaxation period (IVRP) was assessed by simultaneous M-mode registration of the aortic and mitral valve. Significantly increased values in older individuals (41 to 72 years; n=57) as compared to younger subjects (21 to 40 years; n=58) were found for the A/E ratio of the peak velocities (PAV/PEV) (90 versus 64%; p<0.001) and the velocity-time integrals (VTI-A/E) (79 versus 36%; p<0.001), atrial contribution to LV filling (AFF) (45 versus 26%; p<0.001) and isovolumic relaxation period (IVRP) (81 versus 72 ms; p<0.001). Age significantly correlated with PAV/PEV (r=0.74; p<0.001), VTI-A/E (r=0.83; p<0.001), AFF (r=0.81; p<0.001) and IVRP (r=0.74; p<0.001).
Thus, age-related hemodynamic changes during diastole are characterized by a prolongation of IVRP and an increase of atrial contribution to LV filling.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brunckhorst C, Lange HW, Aschenberg W, Rehpenning W, Bleifeld W. Role of transmitral blood flow velocity by Doppler echocardiography in the evaluation of coronary artery disease. Clin Cardiol 1990; 13: 108–14.
Friedman BJ, Drinkovic N, Miles H, Shih WJ, Mazzoleni A, De Maria AN. Assessment of left ventricular diastolic function: comparison of Doppler and gated blood pool scintigraphy. J Am Coll Cardiol 1986; 8: 1348–54.
Fujii J, Yazaki Y, Sawada H, Aizawa T, Watanabe H, Kato H. Noninvasive assessment of left and right ventricular filling in myocardial infarction with a two-dimensional Doppler echocardiographic method. J Am Coll Cardiol 1985; 5: 1155–60.
Gardin JM, Rohan MK, Davidson DM, Dabestani A, Sklansky M, Garcia R, Knoll ML, White TB, Gardin SK, Henry WL. Doppler transmitral flow velocity parameters: Relationship between age, body surface area, blood pressure and gender in normal subjects. Am J Noninvas Cardiol 1987; 1: 3–10.
Grossman W, McLaurin LP. Diastolic properties of the left ventricle. Ann Intern Med 1976; 84: 316–26.
Innouye I, Massie B, Loge D. Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension. Am J Cardiol 1984; 53: 120–6.
Miller TR, Grossman SJ, Schectman KB, Biello DR, Ludbrook PA, Ehsani AA. Left ventricular diastolic filling and its association with age. Am J Cardiol 1986; 58: 531–5.
Nishimura RA, Abel MD, Hatle LK, Tajik AJ. Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography. Part II. Clinical Studies. Mayo Clin Proc 1989; 64: 181–204.
Ormiston JA, Shah PM, Tei C, Wong M. Size and motion of the mitral valve annulus in man. A two dimensional echocardiographic method and findings in normal subjects. Circulation 1981; 64: 113–20.
Rokey R, Kuo L, Zoghbi WA, Limacher MC, Quinones MA. Determination of parameters of left ventricular diastolic filling with pulsed Doppler echocardiography: comparison with cineangiography. Circulation 1985; 71: 543–50.
Soufer R, Wohlgelernter D, Vita N. Intact systolic left ventricular function in clinical congestive heart failure. Am J Cardiol 1985; 55: 1032–36.
Spirito P, Barry JM. Influence of aging on Doppler echocardiographic indices of left ventricular diastolic function. Br Heart J 1989; 59: 672–9.
Störk T, Müller R, Ewert C, Piske G, Wienhold S, Hochrein H. Action of nicotine on left ventricular diastolic function in patients with coronary heart disease. Dtsch med Wschr 1990; 115: 610–7.
Störk T, Müller R, Ewert C, Piske G, Wienhold S, Hochrein H. Noninvasive measurement of left ventricular filling pressures by means of transmitral pulsed Doppler ultrasound. Am J Cardiol 1989; 64: 655–60.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Störk, T., Möckel, M., Danne, O. et al. Age-related hemodynamic changes during diastole: a combined M-mode and Doppler echo study. Int J Cardiac Imag 6, 23–30 (1990). https://doi.org/10.1007/BF01798429
Issue Date:
DOI: https://doi.org/10.1007/BF01798429