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Digestive Diseases and Sciences

, Volume 33, Issue 5, pp 619–624 | Cite as

The treatment of gastric ulcer with antisecretory drugs

Relationship of pharmacological effect to healing rates
  • C. W. Howden
  • D. B. Jones
  • K. E. Peace
  • D. W. Burget
  • R. H. Hunt
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Abstract

Published clinical trials (N=56) of antisecretory drugs in the treatment of benign gastric ulcer were reviewed. Composite healing rates for various drug regimens were calculated using a method previously described for duodenal ulcer. Healing rates were compared with data on suppression of intragastric acidity to see if any relationship was evident. No significant correlations between the two existed, unless placebo data were included in the analysis. Correlations were stronger with suppression of total 24-hr rather than nocturnal acidity. Using Williams' method for assessing trends, it was found that an increase in antisecretory effect is not associated with a concomitant increase in healing rates. Duration of medical treatment is the single most important factor in healing of benign gastric ulcer; healing rates for all drug regimens and placebo show a consistent increase with prolongation of treatment.

Key words

gastric ulcer H2-receptor antagonists omeprazole meta-analysis 

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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • C. W. Howden
    • 1
    • 2
    • 3
  • D. B. Jones
    • 1
    • 2
    • 3
  • K. E. Peace
    • 1
    • 2
    • 3
  • D. W. Burget
    • 1
    • 2
    • 3
  • R. H. Hunt
    • 1
    • 2
    • 3
  1. 1.Department of Materia MedicaUniversity of Glasgow, Stobhill General HospitalGlasgowScotland, UK
  2. 2.Division of GastroenterologyMcMaster UniversityHamiltonCanada
  3. 3.Department of BiostatisticsThe Medical College of VirginiaRichmond

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