Digestive Diseases and Sciences

, Volume 33, Issue 5, pp 558–564 | Cite as

Effects of intravenous and intraduodenal fat on jejunal motility and on plasma cholecystokinin in man

  • C. Guedon
  • P. Ducrotte
  • J. A. Chayvialle
  • E. Lerebours
  • P. Denis
  • R. Colin
Original Articles

Abstract

The effects of intravenous and intraduodenal fat on jejunal motility were studied in nine normal volunteers. Using a nitrogen hydraulic infusion system, recording was performed continuously during 4 hr of fasting and 5 hr of 100 ml/hr infusion of fat (Intralipid 10%) given either intraduodenally (group ID) or intravenously (group IV) and 9 hr after the end of fat administration successively. The two experiments were performed at seven-day intervals in random order. In six of the nine subjects, a third experiment, in which 20 g of cholestyramine was given by mouth during intraduodenal fat infusion (group ID + C), was carried out. Venous blood samples were drawn for measurement of serum triglyceride levels and radioimmunoassay of plasma cholecystokinin. Intraduodenal fat, alone or plus cholestyramine, induced a significant reduction in incidence of phase III of the migrating motor complex. Intravenous fat reduced the incidence of phase III. However, this reduction was significant only during the last 3 hr of fat infusion, corresponding to the highest serum triglyceride concentration. In the three groups, fat infusion induced a significant increase in duration of phase II, leading to a postprandial-like pattern. Plasma cholecystokinin increased significantly in the three groups during fat administration, with a significant positive correlation between serum triglyceride concentration and plasma cholecystokinin in the group IV. The data suggest that, in addition to its known inhibitory effects on activity fronts when acting luminally, fat given intravenously may inhibit phase III activity. The effects in both instances may be mediated in part by cholecystokinin.

Key words

intravenous fat intraduodenal fat jejunum motility plasma cholecystokinin 

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References

  1. 1.
    Sarna SK: Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 89:894–913, 1985Google Scholar
  2. 2.
    Lee KY, Kim MS, Chey WY: Effects of a meal and gut hormones on plasma motilin and duodenal motility in dog. Am J Physiol 238:280–283, 1980Google Scholar
  3. 3.
    Himeno S, Tarui S, Kanayama S, Kuroshima T, Shinomura Y, Hayashi C, Tateishi K, Imagawa K, Hashimura E, Hamaoka T: Plasma cholecystokinin response after ingestion of liquid meal and intraduodenal infusion of fat, amino acids, or hydrochloric acid in man: Analysis with region specific radioimmunoassay. Am J Gastroenterol 78:703–707, 1983Google Scholar
  4. 4.
    Hopman WPM, Jansen JBMJ, Lamers CBHW: Comparative study of the effects of equal amounts of fat, protein and starch on plasma cholecystokinin in man. Scand J Gastroenterol 20:843–847, 1985Google Scholar
  5. 5.
    Lilja P, Wiener I, Inove K, Fried GM, Greeley GH, Thompson JC: Release of cholecystokinin in response to food and intraduodenal fat in pigs, dogs and man. Surg Gynecol Obstet 159:557–561, 1984Google Scholar
  6. 6.
    Sakamoto T, Greeley GH, Fujimura M, Thompson JC: Effect of fat and somatostatin on release of secretin and cholecystokinin in dogs. Dig Dis Sci 29(suppl):72S, 1984Google Scholar
  7. 7.
    Koop I, Koop H, Arnold R: Effect of cholestyramine on fat-induced cholecystokinin release. Dig Dis Sci 29 (suppl):45S, 1984Google Scholar
  8. 8.
    Schang JC, Dauchel J, Sava P: Specific effects of different foods components on intestinal motility. Eur Surg Res 10:425–432, 1978Google Scholar
  9. 9.
    Schang JC, Sava P, Angel F, Lambert A, Marescaux J, Grenier JF: Influence de l'absorption intestinale sur la motricité de l'intestin grÊle. Etude électromyographique chez le chien. Gastroenterol Clin Biol 5:490–495, 1981Google Scholar
  10. 10.
    Arndorfer RC, Stef JJ, Dodds WJ, Linehan JH, Hogan WJ: Improved infusion system for intraluminal esophageal manometry. Gastroenterology 73:23–27, 1977Google Scholar
  11. 11.
    Bucolo G, David H: Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 19:476–482, 1973Google Scholar
  12. 12.
    Miazza B, Palma R, Lachance JR, Chayvialle JA, Jonard PP, Modigliani R: Jejunal secretory effect of intraduodenal food in humans. A comparison of mixed nutrients, proteins, lipids and carbohydrates. Gastroenterology 88:1215–1222, 1985Google Scholar
  13. 13.
    Eysselein VE, Bottcher W, Kauffman JR, Walsh JH: Molecular heterogeneity of canine cholecystokinin in portal and peripheral plasma. Regul Peptides 9:173–185, 1984Google Scholar
  14. 14.
    Kerlin P, Phillips S: Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology 82:694–700, 1982Google Scholar
  15. 15.
    Rees WDW, Malagelada JR, Miller, LJ, Go VLW: Human interdigestive and postprandial gastrointestinal motor and gastrointestinal hormone pattern. Dig Dis Sci 27:321–329, 1982Google Scholar
  16. 16.
    Vantrappen GR, Janssens J, Hellemans J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166, 1977Google Scholar
  17. 17.
    Kumar D, Wingate DL, Ruckebusch Y: Circadian variation in propagation velocity of the migrating motor complex. Gastroenterology 91:926–930, 1986Google Scholar
  18. 18.
    Cortot A, Phillips QD, Malagelada JR: Gastric emptying of lipids after ingestion of an homogenized meal. Gastroenterology 76:939–944, 1979Google Scholar
  19. 19.
    Weisbrodt NW, Copeland EM, Thor PJ, Dudrick SJ: The myoelectric activity of the small intestine of the dog during total parenteral nutrition. Proc Soc Exp Biol Med 153:121–124, 1976Google Scholar
  20. 20.
    Weisbrodt NW: Motility of the small intestine.In Physiology of the Gastrointestinal Tract, 2 ed. LR Johnson (ed). New York, Raven Press, 1987, pp 631–663Google Scholar
  21. 21.
    Varner AA, Isenberg JI, Elashoff JD, Lamers CBHW, Maxwell V, Shulkes AA: Effect of intravenous lipid on gastric acid secretion stimulated by intravenous aminoacids. Gastroenterology 79:873–876, 1980Google Scholar
  22. 22.
    Konturek SJ, Konturek J, Cieszkowski M, Ebert R, Creutzfeldt W: Comparison of gastric inhibitory polypeptide and intraduodenal or intravenous fat on gastric acid secretion from vagally innervated and denervated canine stomach. Dig Dis Sci 31:49–56, 1986Google Scholar
  23. 23.
    Konturek SJ, Tasler J, Cieszkowski M: Intravenous amino acids and fat stimulate pancreatic secretion. Am J Physiol 236:E678-E684, 1979Google Scholar
  24. 24.
    Edelman K, Valenzuela JE: Effect of intravenous lipid on human pancreatic secretion. Gastroenterology 85:438–444, 1983Google Scholar
  25. 25.
    Niederau C, Sonnenberg A, Erckenbrech T: Effects of intravenous infusion of aminoacids, fat or glucose on unstimulated pancreatic secretion in healthy humans. Dig Dis Sci 30:445–455, 1985Google Scholar
  26. 26.
    Hopman WPM, Kerstens PJSM, Jansen JBMJ, Rosenbusch G, Lamers CBHW: Effect of graded physiologic doses of cholecystokinin on gallbladder contraction measured by ultrasonography. Determination of threshold dose-response relationships and comparison with intraduodenal bilirubin output. Gastroenterology 89:1242–1247, 1985Google Scholar
  27. 27.
    Walsh JH, Lamers CB, Valenzuela JE: Cholecystokinin-octapeptide-like immunoreactivity in human plasma. Gastroenterology 82:438–444, 1982Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • C. Guedon
    • 1
    • 2
  • P. Ducrotte
    • 1
    • 2
  • J. A. Chayvialle
    • 1
    • 2
  • E. Lerebours
    • 1
    • 2
  • P. Denis
    • 1
    • 2
  • R. Colin
    • 1
    • 2
  1. 1.Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle C.H.URouen CédexFrance
  2. 2.HÔpital Edouard HerriotINSERM U 45LyonFrance

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