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Services for thalassaemia as a model for cost-benefit analysis of genetics services

  • Workshop On Screening And Economics
  • Published:
Journal of Inherited Metabolic Disease

Summary

Economic appraisal of genetics services is usually limited to consideration of financial costs and benefits, but this can generate misunder-standings about the aims of these services. We propose a general framework for economic analysis that includes non-financial costs and benefits, and the concept of genetic fitness.

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References

  • Angastiniotis, M. A., Kyriakidou, S. and Hadjiminas, M. How thalassaemia was controlled in Cyprus.World Health Forum 7 (1986) 291–297

    Google Scholar 

  • Attanasio, E., Gallanello, R. and Rossi-Mori, A. Analisi costi-benefici di uno intervento preventivo per la talassemia. In:La Preventione delle Malattie Microcitemice. Editioni Minerva Medica, Roma, 1980, pp. 277–284

    Google Scholar 

  • Chamberlain, J. Human benefits and costs of a national screening programme for neural tube defects.Lancet 2 (1978) 1293–1296

    Google Scholar 

  • Drummond, M. F.Principles of Economic Appraisal in Health Care. Oxford Medical Publications, Oxford University Press, Oxford, 1980.

    Google Scholar 

  • Fraser, G. R. The short-term reduction in birth incidence of recessive diseases as a result of genetic counselling after the birth of an affected child.Hum. Hered. 22 (1972) 1–6

    Google Scholar 

  • Gill, M., Murday, V. and Slack, J. An economic appraisal of screening for Down's syndrome in pregnancy using maternal age and serum alpha fetoprotein concentration.Soc. Sci. Med. 24 (1986) 725–731.

    Google Scholar 

  • Hagard, S. and Carter, F. A. Preventing the births of infants with Down's syndrome: a cost-benefit analysis.Br. Med. J. 1 (1976) 753–756

    Google Scholar 

  • Henderson, J. B. Measuring the benefits of screening for neural tube defects.J. Epidemiol. Commun. Health 36 (1982) 214–219

    Google Scholar 

  • Loukopolous, D. (ed.).Prenatal Diagnosis of Thalassaemia and the Haemoglobinopathies. CRC Press Inc., Boca Raton, Florida, 1988

    Google Scholar 

  • Modell, B. and Berdoukas, V.The Clinical Approach to Thalassaemia. Grune and Stratton, New York, 1984

    Google Scholar 

  • Modell, B. and Petrou, M. Comprehensive management of thalassaemia major.Arch. Dis. Child. 58 (1983) 1026–1030

    Google Scholar 

  • Modell, B., Ward, R. H. T. and Fairweather, D. V. I. Effect of introducing antenatal diagnosis on the reproductive behaviour of families at risk for thalassaemia major.Br. Med. J. 2 (1980) 737

    Google Scholar 

  • Modell, B., Kuliev, A. K. and Wagner, M.Community Genetics Services in Europe. WHO Regional Office for Europe, Public Health In Europe Series. (In press)

  • Old, J. M., Fitches, A., Heath, C., Thein, S. L., Weatherall, D. J., Warren, R., McKenzie, C., Rodeck, C. H., Modell, B., Petrou, M. and Ward, R. H. T. First trimester fetal diagnosis for the haemoglobinopathies: report on 200 cases.Lancet 2 (1986) 763–766

    Google Scholar 

  • Ostrowsky, J. T., Lippman, A. and Scriver, C. R. Cost-benefit analysis of a thalassemia disease prevention programme.Am. J. Public Health 75 (1985) 732–736

    Google Scholar 

  • Royal College of Physicians.Prenatal Diagnosis and Genetic Screening: Community and Service Implications. The Royal College of Physicians of London, 1989

  • Sadovnik, A. D. and Baird, P. A. A cost-benefit analysis of prenatal diagnosis of Down syndrome and neural tube defects in older mothers.Am. J. Med. Genet. 10 (1981) 367–378

    Google Scholar 

  • World Health Organization. Advisory Group on Hereditary Diseases.Community Approaches to the Control of Hereditary Diseases. Unpublished WHO document HMG/WG/85.4, 1985. [Can be obtained free of charge from, The Hereditary Diseases Programme, WHO, Geneva, Switzerland]

  • World Health Organization.The Haemoglobinopathies in Europe. WHO Regional Office for Europe, unpublished report IPC/MCH 110 (1987). (Can be obtained free of charge from: Maternal and Child Health Division, WHO Regional Office for Europe, 8 Scherfigsvej, DK-2100, Copenhagen, Denmark)

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Modell, B., Kuliev, A.M. Services for thalassaemia as a model for cost-benefit analysis of genetics services. J Inherit Metab Dis 14, 640–651 (1991). https://doi.org/10.1007/BF01797934

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  • DOI: https://doi.org/10.1007/BF01797934

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