Abstract
Intravascular ultrasound cross-sectional imaging of the atherosclerotic artery may be employed to guide plaque ablation by spark erosion, atherectomy, laser irradiation or other means. To assess whether in the coronary artery the echolucent zone of the three-layered ultrasound appearance of muscular arteries might be a reliable boundary to halt transluminal ablative angioplasty, epicardial coronary arteries were scanned under pressure over a distance of 4–8 cm at 1 mm intervals. A 5.2F catheter with a 30 MHz transducer rotating at 600 RPM was used. In 419 images from four post-mortem hearts, aged at death 22, 31, 56 and 82 years, the presence of a distinct echolucent zone was scored as percentage of the wall circumference. The median scores were 0%, 0%, 10% and 75%, respectively. In the three youngest hearts, the three-layered appearance was largely absent. In the 82 year old heart, in contrast, the three-layered appearance could generally be identified. Within subjects, the presence of an echolucent zone was variable in location. Qualitatively, neither abundant medial elastin tissue nor a reduced medial thickness could explain the absence of an echolucent zone when the ultrasound image was compared to the corresponding microscopic section.
The results show that in the 82 year old heart, 30 MHz intravascular ultrasound discrimination of coronary wall layers would be adequate to guide transluminal plaque ablation. In the younger hearts, guided ablation would fail due to the limited presence of a distinct echolucent zone as an ultrasound landmark of the media. Whether the presence or absence of an echolucent zone is related to age remains to be determined.
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Popp RL. Echocardiography (Review). N Engl J Med 1990; 323: 101–9 and 165–72.
Bom N, Slager CJ, Egmond FC, Lancée CT, Serruys PW. Intra-arterial ultrasound imaging for recanalization by spark erosion. Ultrasound Med Biol 1988; 14: 257–61.
Pandian NG, Kreis A, Brockway B, Isner JM, Sacharoff A, Boleza E, Caro R, Muller D. Ultrasound angioscopy: real time, two-dimensional, intraluminal ultrasound imaging of blood vessels. Am J Cardiol 1988; 62: 493–4.
Yock PG, Johnson EL, Linker DT. Intravascular ultrasound: development and clinical potential. Am J Card Imaging 1988; 2: 185–93.
Meyer CR, Chiang EH, Fechner KP, Fitting DW, Williams DM, Buda AJ. Feasibility of high resolution, intravascular ultrasonic imaging catheters. Radiology 1988; 168: 113–6.
Bom N, Ten Hoff H, Lancée CT, Gussenhoven WJ, Bosch JG. Early and recent intraluminal ultrasound devices. Int J Card Imaging 1989; 4: 79–88.
Bom N, Roelandt JRTC (eds). Intravascular Ultrasound. Techniques, Development, Clinical Perspectives. Dordrecht: Kluwer Academic Publishers, 1989 (also: Int J Card Imaging 1989; 4: 79–216).
Aretz HT, Martinelli MA, LeDet EG. Intraluminal ultrasound guidance of transverse laser coronary atherectomy. Int J Card Imaging 1989; 4: 153–7.
Borst C, Rienks R, Mali WPThM, Van Erven L. Laser ablation and the need for intra-arterial imaging. Int J Card Imaging 1989; 4: 127–33.
Yock PG, Linker DT, White NW, Rowe MH, Selmon MR, Robertson GC, Hinchara T, Simpson JB. Clinical applications of intravascular ultrasound imaging in atherectomy. Int J Card Imaging 1989; 4: 117–25.
Gussenhoven EJ, Essed CA, Lancée CT, Mastik F, Frietman P, Van Egmond FC, Reiber J, Bosch H, Van Urk H, Roelandt J, Bom N. Arterial wall characteristics determined by intravascular ultrasound imaging: anin vitro study. J Am Coll Cardiol 1989; 14: 947–52.
Gussenhoven WJ, Essed CE, Frietman P, Mastik F, Lancée C, Slager C, Serruys P, Gerritsen P, Pieterman H, Bom N. Intravascular echographic assessment of vessel wall characteristics: a correlation with histology. Int J Card Imaging 1989; 4: 105–16.
Hodgson JMcB, Graham SP, Savakus AD, Dame SG, Stephens DN, Dhillon PS, Brands D, Sheehan H, Eberle MJ. Clinical percutaneous imaging of coronary anatomy using an over-the-wire ultrasound catheter system. Int J Card Imaging 1989; 4: 187–93.
Tobis JM, Mallery JA, Gessert J, Griffith J, Mahon D, Bessen M, Moriuchi M, McLeay L, McRae M, Henry WL. Intravascular ultrasound cross-sectional arterial imaging before and after balloon angioplastyin vitro. Circulation 1989; 80: 873–82.
Nishimura RA, Edwards WD, Warnes CA, Reeder GS, Holmes DR, Tajik AJ, Yock PG. Intravascular ultrasound imaging:in vitro validation and pathologic correlation. J Am Coll Cardiol 1990; 16: 145–54.
Potkin BN, Bartorelli AL, Gessert JM, Neville RF, Almagor Y, Roberts WC, Leon MB. Coronary artery imaging with intra-vascular high-frequency ultrasound. Circulation 1990; 81: 1575–85.
Yock PG, Linker DT. Intravascular ultrasound. Looking below the surface of vascular disease (Editorial Comment). Circulation 1990; 81: 1715–18.
Waller BF. Anatomy, histology and pathology of the major epicardial coronary arteries relevant to echocardiographic imaging techniques. J Am Soc Echo 1989; 2: 232–52.
Gussenhoven E, Pijl A, Frietman P, Gerritsen P, Essed CE, Roelandt J, Rysterborgh H, Lancée CT, van Egmond F, Bom N. Thinning of the media in atherosclerosis: anin vitro intravascular echographic study (abstr). Circulation 1990; 82 (Suppl. III): III-458.
Gussenhoven EJ, The SHK, Serruys PW, Van Urk H, Pieterman H, Van Egmond FC, Roelandt JR, Lancée CT, Wenguang L, Zhong Y. Intravascular ultrasound and vascular intervention. J Interv Card 1991; 4: 41–8.
Gussenhoven EJ, The SHK, Gerritsen P, Van Urk H, Van Egmond FC, Roelandt JR, Lancée CT, Bom N. Case Report. Real-time intravascular ultrasonic imaging before and after balloon angioplasty. J Clin Ultrasound 1991; 19: 294–7.
Fitzgerald PJ, Cogburn MA, Wing K, et al. Determination of arterial wall components using intravascular backscatter analysis (abstr). Circulation 1990; (Suppl. III): III-458.
Fitzgerald PJ, St. Goar FG, Kao AK, et al. Intravascular ultrasound imaging of coronary arteries: is three layers the norm? (abstr). J Am Coll Cardiol 1991; 17 (Suppl): 217A.
St. Goar FG, Pinto FJ, Alderman EL, Valantine HA, Popp RL. Intracoronary ultrasound in cardiac transplant recipients:in vivo evaluation of angiographically silent intimal thickening (abstr). J Am Coll Cardiol 1991; 17 (Suppl): 102A.
Gregory KW, Martinelli MA, Aretz TH, et al. Intravascular ultrasound guided Holmium laser atherectomy (abstr). Circulation 1990; 82 (Suppl III): III-677.
Schmucker ML, Howard PF, Schub DE, et al. Does intracoronary ultrasound prevent deep cuts during coronary atherectomy? (abstr). Circulation 1990; 82 (Suppl III): III-440.
Anderson RH, Becker AE. Cardiac anatomy. An integrated text and colour atlas. London: Gower Medical Publishing 1984, p 6.14.
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Borst, C., Savalle, L.H., Smits, P.C. et al. Imaging of post-mortem coronary arteries by 30 MHz intravascular ultrasound. Int J Cardiac Imag 6, 239–246 (1991). https://doi.org/10.1007/BF01797855
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DOI: https://doi.org/10.1007/BF01797855