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Intracardiac echocardiography: current developments

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Abstract

Intracardiac echocardiography refers to the method of imaging cardiac structures from intracardiac locations with the use of ultrasound catheters. Advances in catheter-based interventional cardiologic procedures to treat cardiovascular lesions and the problems encountered during those procedures due to inadequate guidance provided by fluoroscopy have given the impetus to develop other guidance modalities. Experimental explorations with intracardiac ultrasound probes have indicated that detailed visualization of cardiac structures in real-time is possible by intracardiac ultrasound. Recent advances in catheter-based ultrasound technology make it feasible to safely pass small-sized catheters in humans into various intracardiac locations and acquire images of valvular structures and various chambers. Experience with 20 MHz ultrasound catheters indicates that high resolution images of normal and abnormal structures can be obtained if the catheter is manipulated close to the region of interest. The problem of the limited depth of field associated with 20 MHz catheters has led to the fabrication of catheters with lower frequency ultrasound elements. Experimental and clinical experience with 12.5 MHz ultrasound catheters points to the capability and potential of intracardiac echocardiography to not only display normal structures but also aid in the identification of valvular abnormalities, chamber dysfunction and pericardial effusions. In addition, aortic disorders such as acute dissection, coarctation and atherosclerotic disease could be delineated. Similarly, abnormalities involving the pulmonary arteries such as pulmonary embolism, organized thrombi, peripheral pulmonary arterial stenoses, and pulmonary hypertension-induced vascular changes could be recognized. Many modifications in the catheter design are being explored. With further work in the area of catheter technology and ultrasound image processing, intracardiac echocardiography is likely to become a clinical tool.

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References

  1. Rahimtoola SH. Catheter balloon valvuloplasty of aortic and mitral stenosis in adults. Circulation 1987; 75: 895–901.

    Google Scholar 

  2. Mullins CE. Pediatric and congenital therapeutic cardiac catheterization. Circulation 1989; 79: 1153–1159.

    Google Scholar 

  3. Buxton AE. Catheter ablation of atrioventricular bypass tracts: Still an investigational procedure. Circulation 1989; 79: 1388–1390.

    Google Scholar 

  4. Herrmann HC, Kleaveland JP, Hill JA, Cowley MJ, Margolis JR, Nocero MA, Zalewski A, Pepine CJ. The M-Heart percutaneous balloon mitral valvuloplasty registry: Initial results and early follow-up. J Am Coll Cardiol 1990; 15: 1221–1226.

    Google Scholar 

  5. Pandian NG, Isner JM, Hougen TJ, Desnoyers MR, McInerney K, Salem DN. Percutaneous balloon valvuloplasty of mitral stenosis aided by cardiac ultrasound. Am J Cardiol 1987; 59: 380–381.

    Google Scholar 

  6. Kronzon I, Tunick PA, Schwinger ME et al. Transesophageal echocardiography during percutaneous mitral valvuloplasty. J Am Soc Echo 1989; 2: 380–385.

    Google Scholar 

  7. Gamble WJ, Innis RE. Experimental intracardiac visualization. N Engl J Med 1967; 276: 1397–1403.

    Google Scholar 

  8. Salem DN, Pandian NG, Udelson J. Percutaneous balloon valvuloplasty and coronary angioplasty: What kind of guidance would be useful during the performance of these procedures? Echocardiography 1990; 7: 397–402.

    Google Scholar 

  9. Pandian NG, Kreis A, Brockway B, Isner JM, Sacharoff A, Boleza E, Caro R, Muller D. Ultrasound angioscopy; Realtime, two-dimensional, intraluminal ultrasound imaging of blood vessels. Am J Cardiol 1988; 62: 493–494.

    Google Scholar 

  10. Yock PG, Johnson EL, Linker DT. Intravascular ultrasound: Development and clinical potential. Am J Cardiac Imaging 1988; 2: 185–193.

    Google Scholar 

  11. Tobis J, Mallery J, Gessert J, Griffith J, Mahon D, Bessen M, Moriuchi M, McLeay L, McRae M, Henry WL. Intravascular ultrasound cross-sectional arterial imaging before and after balloon angioplastyin vitro. Circulation 1989; 80: 873–882.

    Google Scholar 

  12. Hodgson J, Graham SP, Savakus AD, Dame SG, Stephens DN, Brands DD, Sheehan H, Eberle MJ. Clinical percutaneous imaging of coronary anatomy using an over-the-wire ultrasound catheter system. Int J Card Imaging 1989; 4: 187–193.

    Google Scholar 

  13. Pandian NG, Kreis A, Brockway B. Detection of intraarterial thrombus by intravascular high frequency two-dimensional ultrasound. Am J Cardiol 1990; 65: 1280–1283.

    Google Scholar 

  14. Potkin BN, Bartorelli AL, Gessert JM, Neville RF, Almagor Y, Robert WC, Leon MB. Coronary artery imaging with intravascular high frequency ultrasound. Circulation 1990; 81: 1575–1585.

    Google Scholar 

  15. Pandian NG, Kreis A, O'Donnell T. Intravascular ultrasound estimation of arterial stenosis. J Am Soc Echo 1989; 2: 390–396.

    Google Scholar 

  16. Gussenhoven EJ, Essed CE, Lancée CT, Mastik F, Frietman P, Egmond FCV, Feiber J, Bosch H, Urk UV, Roelandt J, Bom N. Arterial wall characteristics determined by intravascular ultrasound imaging: Anin vitro study. J Am Coll Cardiol 1989; 14: 947–952.

    Google Scholar 

  17. Pandian NG, Kreis A, Weintraub A, Motarjeme A, Desnoyers M, Isner JM, Konstam M, Salem DN, Millen V. Realtime intravascular ultrasound imaging in humans. Am J Cardiol 1990; 65: 1392–1396.

    Google Scholar 

  18. Nissen SE, Grines CL, Gurley JC, Sublett K, Haynie D, Diaz C, Booth DC, DeMaria AN. Application of a new phased-array ultrasound imaging catheter in the assessment of vascular dimensions.In vivo comparison to cineangiography. Circulation 1990; 81: 660–666.

    Google Scholar 

  19. Pandian NG, Weintraub A, Kreis A, Schwartz SL, Konstam MA, Salem DN. Intracardiac, intravascular, two-dimensional, high-frequency ultrasound imaging of pulmonary artery and its branches in humans and animals. Circulation 1990; 81: 2007–2012.

    Google Scholar 

  20. Harrison JK, Sheikh KH, Davidson CJ, Kisslo KB, Leithe ME, Himmelstein SI, Kanter RJ, Bashore TM. Balloon angioplasty of coarctation of the aorta evaluated with intravascular ultrasound imaging. J Am Coll Cardiol 1990; 15: 906–909.

    Google Scholar 

  21. Pandian NG, Kreis A, Brockway B, Sacharoff A, Caro R. Intravascular high frequency two-dimensional ultrasound detection of arterial dissection and intimal flaps. Am J Cardiol 1990; 65: 1278–1280.

    Google Scholar 

  22. Nishimura RA, Edwards WD, Warnes CA, Reeder GS, Holmes DR, Tajik AJ. Intravascular ultrasound imaging:In vitro validation and pathologic correlation. J Am Coll Cardiol 1990; 16: 145–154.

    Google Scholar 

  23. Kreis A, Brockway B, Pandian NG.In vivo intravascular ultrasound angioscopic evaluation of venous circulation using a high frequency ultrasound catheter (abstract). Circulation 1989; 80: II-564.

    Google Scholar 

  24. Graham S, Brands D, Savakus A, Hodgson J. Utility of an intravascular ultrasound imaging device for arterial wall definition and atherectomy guidance (abstract). J Am Coll Cardiol 1989; 13: 222A.

  25. Yock PG, Fitzgerald P, White N, Linker DT, Angelsen BAJ. Intravascular ultrasound as a guiding modality for mechanical atherectomy and laser photoablation. Echocardiography 1990; 7: 425–432.

    Google Scholar 

  26. Cieszynski T. Intracardiac method for the investigation of structure of the heart with the aid of ultrasonics. Arch Immun Ter Dosw 1960; 8: 551–553.

    Google Scholar 

  27. Kossoff G. Diagnostic applications of ultrasound in cardiology. Australas Radiol 1966; 10: 101–106.

    Google Scholar 

  28. Kimoto S, Omoto R, Tsunemoto M. Ultrasonic tomography of the liver and detection of heart atrial septal defect with the aid of ultrasonic intravenous probes. Ultrasonics 1964; 2: 82–86.

    Google Scholar 

  29. Carleton RA, Sessions RW, Graettinger JS. Diameter of heart measured by intracavitary ultrasound. Med Res Engng 1969. May/June 28–32.

  30. Eggleton RC, Townsend C, Kossoff G, Herrick J, Hunt R, Templeton G, Mitchell JH. Computerised ultrasonic visualization of dynamic ventricular configuration. 8th ICMBE July 1969 Session 10–13.

  31. Bom N, Lancée CT, Van Egmond FC. An ultrasonic intracardiac scanner. Ultrasonics 1972; 10: 72–76.

    Google Scholar 

  32. Conetta DA, Christie LG, Pepine CJ, Nichols WW, Conti CR. Intracardiac M-mode echocardiography for continuous left ventricular monitoring: methods and potential application. Cathet Cardiovasc Diagn 1979; 5: 135–143.

    Google Scholar 

  33. Glassman E, Kronzon I. Transvenous intracardiac echocardiography. Am J Cardiol 1981; 47: 1255–1259.

    Google Scholar 

  34. Schwartz SL, Pandian NG, Kusay BS, Kumar R, Weintraub A, Katz SE, Aronovitz M. Realtime intracardiac two-dimensional echocardiography: An experimental study ofin vivo feasibility, imaging planes, and echocardiographic anatomy. Echocardiography 1990; 7: 443–456.

    Google Scholar 

  35. Schwartz SL, Kusay BS, Pandian NG, Aronovitz M, Konstam MA, Salem D. Utility ofin vivo, intracardiac 2-dimensional echocardiography in the assessment of myocardial risk area and myocardial dyssynergy during coronary occlusion and reperfusion (abstract). Circulation 1989; 80: II-374.

    Google Scholar 

  36. Schwartz S, Kusay B, Pandian N, Kumar R, Katz S, Aronovitz M, Konstam M, Haik B, Salem D. Intracardiac echocardiographic guidance and monitoring during aortic and mitral balloon valvuloplasty:In vivo experimental studies (abstract). J Am Coll Cardiol 1990; 15: 104A.

  37. Seward JB, Khandheria BK, McGregor CGA, Locke TJ, Tajik AJ. Transvascular and intracardiac two-dimensional echocardiography. Echocardiography 1990; 7: 465–468.

    Google Scholar 

  38. Valdes-Cruz LM, Sideris E, Sahn DJ, Murillo-Olias A, Knudson O, Omoto R, Kyo S, Gulde R. Transvascular intracardiac applications of a miniaturized phased-array ultrasonic endoscope: Initial experience with intracardiac imaging in piglets. Circulation 1991; 83: 1023–1027.

    Google Scholar 

  39. Weintraub A, Pandian NG, Sanzobrino BW, Pachucki DO, Katz S, Schwartz S, Konstam M, Salem D, McKay RG, Gillam LD. Intravascular and intracardiac ultrasound imaging of the heart and great vessels: Practicality, utility and safety — Experience in 100 patients (abstract). Circulation 1990; 82: III-441.

    Google Scholar 

  40. Pandian NG, Schwartz S, Hsu TL, Weintraub A, Katz S, Aronovitz M, Konstam M, Salem D, Kreis A. Intracardiac echocardiography — Experimental observations on intracavitary imaging of cardiac structures with 20 MHz ultrasound catheters. Echocardiography 1991; 8: 127–134.

    Google Scholar 

  41. Sanxobrino BW, Mitchel JF, Chameides L, Diana DJ, Leopold HB, Hirst JA, Pandian N, McKasy RG, Gillam LD. Intracardiac two-dimensional ultrasonic assessment of atrial septal defects: human studies (abstract). Circulation 1990; 82: III-31.

    Google Scholar 

  42. Berns E, Mitchel J, Mahran R, Therict P, Iyengar J, Kimura Y, McKay R, Gillam L. Ablating catheter placement under direct visualization with the intravascular ultrasound probe: A potential aid to ablative therapy of arrhythmias (abstract). J Am Coll Cardiol 1990; 15: 19A.

  43. Ricou F, Nicod PH, Moser KM, Peterson KL. Catheterbased intravascular imaging of chronic thromboembolic pulmonary disease. Am J Cardiol 1991; 67: 749–752.

    Google Scholar 

  44. Kumar R, Katz S, Tutar A, Aronovitz M, Salem D, Gillam LD, McKay RG, Pandian N. A new method to diagnose acute pulmonary thromboembolism: Intravascular ultrasound (abstract). Circulation 1990; 82: III-362.

    Google Scholar 

  45. Schwartz S, Pandian N, Katz S, Kumar R, Crowley R, Aronovitz M, Hsu TL. Flow-directed, balloon-floatation intrasvascular ultrasound catheter for percutaneous pulmonary artery imaging and intracardiac echocardiography (abstract). J Am Coll Cardiol 1991; 17: 216A.

  46. Sanzobrino B, Gillam L, McKay R, Chameides L, Diana D, Leopold H, Schwartz S, Katz S, Hsu TL. A direct clinical role for intravascular ultrasound: utility in the assessment and treatment of coarctation of the aorta (abstract). J Am Coll Cardiol 1991; 17: 68A.

  47. Weintraub AR, Schwartz SL, Pandian NG, Katz SE, Kwox OJ, Millan V, Bojar R. Evaluation of acute aortic dissection by intrasvascular ultrasonography. N Engl J Med 1990; 323: 1566–1567.

    Google Scholar 

  48. Pandian NG, Katz S, Kumar R, Tutar A, Schwartz S, Weintraub A, Gillam LD, McKay RG, Konstam M, Salem D, Connolly R, Aronovitz M: Enhanced depth of field in intracardiac 2-D echocardiography with a new, prototype, low frequency (12 MHz, 9F) ultrasound catheter (abstract). Circulation 1990; 82: III-442.

    Google Scholar 

  49. Schwartz S, Weintraub A, Pandian NG, Katz S, Hsu TL, Mandalakas N, Wang P, Estes M, Konstam M, Salem D, Bojar R, Rastegar H. Percutaneous and intraoperative intracardiac echocardiography in humans with the use of a small size, low-frequency ultrasound catheter (abstract). J Am Coll Cardiol 1991; 17: 94A.

  50. Pandian NG, Kumar R, Katz S, Tutor A, Schwartz S, Weintraub A, Gillam L, McKay R, Konstam M, Salem D, Aronovitz M. Real-time intracardiac echocardiography. Echocardiography (in press).

  51. Pandian NG. Intravascular and intracardiac ultrasound imaging. An old concept, now on the road to reality. Circulation 1989; 80: 1091–1094.

    Google Scholar 

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Pandian, N.G., Schwartz, S.L., Weintraub, A.R. et al. Intracardiac echocardiography: current developments. Int J Cardiac Imag 6, 207–219 (1991). https://doi.org/10.1007/BF01797852

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