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Niedermolekulares Heparin: Wie beeinflußt es den Fettstoffwechsel bei chronischen Hämodialysepatienten?

Low molecular weight heparine: Influence on blood lipids in patients on chronic hemodialysis

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Summary

22 patients on chronic hemodialysis underwent low-molecular-weight-heparine (LMWH) (Fragmin, Kabi Chemie Corp., München) instead of conventional heparine (CH) for anticoagulation during dialysis. Blood evaluations before start, 2, 4 and 6 months under LWMH treatment and 3 and 6 months after switching back to CH were performed. During LWMH-treatment whole cholesterol decreased significantly, LDL-cholesterol being the main part accounting for this. HDL-cholesterol and the subfractions of HDL-cholesterol remained nearly unchanged. The apolipoproteins A1 and B decreased significantly, too. Apolipoprotein B decreased during the 6 months LMWH-period continuously, while Apolipoprotein A1 rapidly decreased during the first two months and then stabilized at a lower level. The triglycerides, starting from a normal range level, increased during the first 2 months significantly, then decreased reaching, the starting values again at the end of the LMWH-period. Platelet aggregation induced with collagen showed a significant improvement during the use of LMWH. After switching back to CH the parameters returned to the starting values again.

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Abbreviations

LMWH:

low molecular weight heparine=niedermolekulares Heparin

CH:

conventional heparine=konventionelles Heparin

HD:

Hämodialyse

LDL:

low density lipoprotein

HDL:

high density lipoprotein

SD:

Standardabweichung

GOT:

Glutamat-Oxalacetat-Transaminase (=AST=Aspartat-Aminotransferase)

GPT:

Glutamatr-Pyruvat-Transaminase (=ALT=Alanin-Aminotransferase)

CK:

Creatinkinase

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Authors and Affiliations

  1. Zentrum für Innere Medizin, Nephrologische Abteilung, Katharinenhospital Stuttgart, FRG

    H. Schneider

  2. Institut für Klinische Chemie und Laboratoriumsmedizin, Katharinenhospital Stuttgart, FRG

    Y. Schmitt

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Schneider, H., Schmitt, Y. Niedermolekulares Heparin: Wie beeinflußt es den Fettstoffwechsel bei chronischen Hämodialysepatienten?. Klin Wochenschr 69, 749–756 (1991). https://doi.org/10.1007/BF01797613

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  • DOI: https://doi.org/10.1007/BF01797613

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