Klinische Wochenschrift

, Volume 69, Issue 16, pp 736–741 | Cite as

Insulin autoantibodies as determined by competitive radiobinding assay are positively correlated with impaired beta-cell function — The Ulm-Frankfurt population study

  • N. Yassin
  • J. Seißler
  • M. Glück
  • B. O. Boehm
  • E. Heinze
  • E. F. Pfeiffer
  • W. A. Scherbaum


Out of a random population of 4208 non-diabetic pupils without a family history of Type I diabetes 44 (1.05%) individuals had islet cell antibody (ICA) levels greater or equal to 5 Juvenile Diabetes Foundation (JDF) units. 39 of these ICA-positives could be repeatedly tested for circulating insulin autoantibodies (CIAA) using a competitive radiobinding assay. The results were compared with the insulin responses in the intravenous glucose tolerance tests (IVGTT) and with HLA types. Six pupils were positive for CIAA. All of them had complement-fixing ICA, and 5 of them were HLA-DR4 positive. Three of the 6 showed a first-phase insulin response below the first percentile of normal controls. Our data indicate that in population-based studies CIAA can be considered as a high risk marker for impaired beta-cell function in non-diabetic ICA-positive individuals.

Key words

CIAA CF-ICA Beta-cell function IVGTT HLA 





circulating insulin autoantibodies


enzyme-linked immunosorbent assay


human leukocyte antigen


insulin autoantibodies


cytoplasmic islet cell antibodies


intravenous glucose tolerance test


Juvenile Diabetes Foundation




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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • N. Yassin
    • 1
  • J. Seißler
    • 1
  • M. Glück
    • 1
  • B. O. Boehm
    • 2
  • E. Heinze
    • 3
  • E. F. Pfeiffer
    • 1
  • W. A. Scherbaum
    • 1
  1. 1.Abteilung Innere Medizin IUniversität UlmUlm
  2. 2.Abteilung EndokrinologieUniversität FrankfurtFrankfurt
  3. 3.KinderklinikUniversität UlmUlm

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