The effects of lead ingestion on the body burden of DDT, liver vitamin A and microsomal enzyme activity in the rat

  • W. E. J. Phillips
  • D. C. Villeneuve
  • G. C. Becking


Lead ingestion at 100 and 200 ppm for 36 and 90 days had no effect on the disappearance of DDT residues (and metabolites) from adipose tissue of rats. Lead alone, and lead fed to DDT pre-treated animals had no effect on body weight gain, liver weights, liver vitamin A, liver protein,in vitro liver carboxylesterase activity and pentobarbital sleeping times.


Enzyme Waste Water Adipose Tissue Weight Gain Water Pollution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Roush G., Jr., and Kehoe, R.A. Ann. Rev. Pharmacol.4, 247, 1964.Google Scholar
  2. 2.
    Patterson, C.C. Arch. Environ. Health11, 344, 1965.Google Scholar
  3. 3.
    Schroeder, H.A., and Tipton, I.H. Arch. Environ. Health17, 965, 1968.Google Scholar
  4. 4.
    Villeneuve, D.C., Phillips, W.E.J., and Syrotiuk, John. Bull. Environ. Contamin. Toxicol.5, 125, 1970.Google Scholar
  5. 5.
    Gornall, A.G., Bardawill, C.J., and David, M.M. J. Biol. Chem.177, 751, 1948.Google Scholar
  6. 6.
    Phillips, W.E.J. Can. J. Biochem. Physiol.40, 491, 1962.Google Scholar
  7. 7.
    McCully, K.A., and McKinley, W.P. J.A.C.A.C.47, 725, 1964.Google Scholar
  8. 8.
    Street, J.C. Science146, 1580, 1964.Google Scholar
  9. 9.
    Street, J.C., Chadwick, R.W., Wong, M., Phillips, R.L. J. Agr. Food Chem.14, 545, 1966.Google Scholar
  10. 10.
    Cueto, C., Jr., and Hayes, W.J., Jr. Toxicol. Appl. Pharmacol.7, 481, 1965.Google Scholar
  11. 11.
    Hernberg, S., and Nikkanen, J. Lancet, pg. 63, 1970.Google Scholar
  12. 12.
    Hoppner, K., Phillips, W.E.J., Erdody, P., Murray, T.K., and Perrin, D.E. Canad. Med. Assoc. J.101, 736, 1969.Google Scholar
  13. 13.
    FAO/WHO. Wld. Hlth. Org. Techn. Rep. Ser. no. 373, pg. 15, 1967.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1971

Authors and Affiliations

  • W. E. J. Phillips
    • 1
  • D. C. Villeneuve
    • 1
  • G. C. Becking
    • 1
  1. 1.Department of National Health and WelfareResearch Laboratories, Food and Drug DirectorateOttawaCanada

Personalised recommendations