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Teratogenic studies with 2,4,5-T and 2,4-D in the hamster

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Summary

Commercial samples of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) were feticidal and teratogenic in the golden Syrian hamster when administered orally on days 6 – 10 of organogenesis, and the incidence of effects increased with the content of the impurity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Abnormalities per live litter were clearly related to dose levels of 2,4,5-T in combination with dioxin. With dioxin, the abnormalities caused by 2,4,5-T consisted chiefly of absence of eyelid and delayed head ossification. Dioxin contamination increased the level of hemorrhages in the liveborn, and also produced marked edema.

Terata were produced occasionally with 2,4-dichlorophenoxyacetic acid (2,4-D) and the fetal viability per litter decreased, but neither effect was clearly dose-related. Fused ribs were seen with the greatest frequency among the terata produced by 2,4-D.

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Authors and Affiliations

  1. Department of Health, Education, and Welfare, Division of Toxicology, Food and Drug Administration, Washington, D.C.

    T. F. X. Collins & C. H. Williams

Authors
  1. T. F. X. Collins
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  2. C. H. Williams
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Collins, T.F.X., Williams, C.H. Teratogenic studies with 2,4,5-T and 2,4-D in the hamster. Bull. Environ. Contam. Toxicol. 6, 559–567 (1971). https://doi.org/10.1007/BF01796866

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  • DOI: https://doi.org/10.1007/BF01796866

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