Summary
A single dose of 3 mg. of crystallized 3-methylcholanthrene was implanted into the ventral wall of the gastric antrum of guinea pigs (21 males, 20 females). Diverticula were observed in 12 cases; they were located either in the submucosa or muscularis propria, were usually well circumscribed and showed regular glands and orderly epithelial cells. In two of the diverticula, however, the glands grew into the surrounding tissues. In two other cases there was an infiltrative invasion by the epithelium. In addition, a gastric leiomyosarcoma was observed.
Zusammenfassung
Meerschweinchen beiderlei Geschlechts (21 männliche und 20 weibliche) wurden 3 mg kristallisiertes Methylcholanthren in einer einmaligen Dosis in die Magenwand (nahe dem Pylorus) implantiert. Der Versuch dauerte 515 Tage. Präcanceröse Epithelveränderungen des Magens wurden beobachtet bei 14 von 41 Tieren (34,1%). Divertikel wurden in 12 Fällen festgestellt (zwei von ihnen mit infiltrierenden Veränderungen). Gewöhnlich waren sie gut abgegrentz; sie lagen entweder in der Submucosa oder in der Muscularis propria und zeigten regelmäßige Drüsen und normale Anordnung der Zellen. Zwei Divertikel zeigten ein Eindringen der Drüsen in das benachbarte Gewebe. Die anderen zwei Fälle umfaßten infiltrierende Epithelveränderungen. Ein Leiomyosarkom des Magens wurde ebenfalls beobachtet.
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The authors wish to thank Prof.O. Badínez, Department of Biology, University of Chile, and Prof.R. Barahona, Department of Pathologic Anatomy, Catholic University, for their assistance in the interpretation of some slides of the tissue sections, and Dr.R. Palacios, Bacteriological Institute, National Health Service, for the kind gift of 3-methylcholanthrene (Eastman Kodak Co., Rochester, N.Y.). They are also indebted to Drs.H. Maturana andS. Koref, Department of Biology, for their help during the preparation of this manuscript.
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Zaldívar, R.S.d., Aliaga, C. & Rodríguez, H. Epithelial lesions of the stomach induced in guinea pigs by intramural implantation of 3-methylcholanthrene. Z Krebs-forsch 65, 113–120 (1962). https://doi.org/10.1007/BF01794906
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DOI: https://doi.org/10.1007/BF01794906