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Techniques for measuring renal transit time

European Journal of Nuclear Medicine volume 22, pages 1372–1378 (1995)Cite this article

Abstract

A variety of techniques have been used for quantitative estimation of renal transit time. We compared different indices of transit time in a group of 30 patients having baseline and ACE inhibitor technetium-99m mercaptoacetyltriglycine (MAG3) renography prior to arteriography: peak time, mean transit time, and the ratio of background-subtracted counts at 20 min to those at 3 min. Each index was calculated from whole-kidney ROI, cortical ROI, and cortical factor (by factor analysis). The strongest correlations between angiographic percent of stenosis and transit time index were observed for the peak time (Spearmanρ=0.469,n=53,P <0.005) and for the R20/3 (againρ=0.469,n=53,P <0.005) using the whole-kidney ROI and using only the baseline data without captopril. (Spearman'sρ is simply the correlation coefficient calculated from rank in list, which allows for nonlinear correlation.) Thus simple indices of transit time (whole-kidney peak time and R20/3) correlated as well with the observed pathology as did more complicated methods that required deconvolution, factor analysis, or selection of a cortical ROI.

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Affiliations

  1. Division of Nuclear Medicine, University of Alabama at Birmingham Medical Center, Birmingham, Alabama, USA

    Charles D. Russell, M. Japanwalla, Salma Khan, Johnny W. Scott & Eva V. Dubovsky

  2. Nuclear Medicine Service, V.A. Medical Center — Birmingham, Birmingham, Alabama, USA

    Charles D. Russell, M. Japanwalla, Salma Khan, Johnny W. Scott & Eva V. Dubovsky

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  1. Charles D. Russell
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  2. M. Japanwalla
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  3. Salma Khan
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  4. Johnny W. Scott
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  5. Eva V. Dubovsky
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Russell, C.D., Japanwalla, M., Khan, S. et al. Techniques for measuring renal transit time. Eur J Nucl Med 22, 1372–1378 (1995). https://doi.org/10.1007/BF01791144

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  • DOI: https://doi.org/10.1007/BF01791144

Key words

  • Factor analysis
  • Technetium-99m mercaptoacetyltriglycine
  • Transit time
  • Deconvolution
  • Kidney