Skip to main content
Log in

Zur Frage der Ascorbinsäure-Synthese in der Leber des menschlichen Feten und Frühgeborenen

  • Kurze Wissenschaftliche Mitteilungen
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Zusammenfassung

In isolierten Mikrosomen der Leber von acht menschlichen Frühgeborenen und vier Feten im Alter von durchschnittlich 4 Monaten ließ sich unter optimalen Test-bedingungen keine Gulonolactonoxydaseaktivität nachweisen.

Summary

Gulonolactone oxidase activity was not detectable under optimal test conditions in isolated liver microsomes of 8 human premature infants and 4 fetuses, average age 4 months.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Grollman, A. P., andA. L. Lehninger: Enzymic synthesis ofl-ascorbic acid in different animal species. Arch. Biochem.69, 458 (1957).

    PubMed  Google Scholar 

  2. Burns, J. J.: Missing step in man, monkey and guinea pig required for the biosynthesis ofl-ascorbic acid. Nature (Lond.)180, 553 (1957).

    PubMed  Google Scholar 

  3. Yamada, K., S. Ishikawa, andN. Shimazono: On the microsomal and soluble lactonases. Biochim. biophys. Acta (Amst.)32, 253 (1959).

    PubMed  Google Scholar 

  4. Winkelman, J., andA. L. Lehninger: Aldono- and uronolactonases of animal tissues. J. biol. Chem.233, 794 (1958).

    PubMed  Google Scholar 

  5. Bublitz, C.:l-gulono-γ-lactone oxidase and dehydrogenase. Biochim. biophys. Acta (Amst.)48, 61 (1961).

    Google Scholar 

  6. Kar, N. C., I. B. Chatterjee, N. C. Ghosh, andB. C. Guha: Further observations on the intracellular location and mechanism of action of liver enzymes catalysing the synthesis ofl-ascorbic acid. Biochem. J.84, 16 (1962).

    PubMed  Google Scholar 

  7. Baker, E. M., H. E. Sauberlich, S. J. Wolfskill, W. T. Wallace, andE. E. Dean: Tracer studies of vitamin C utilization in men: Metabolism ofd-glucuronolactone-6-C14,d-glucuronic-6-C14 acid andl-ascorbic-I-C14 acid. Proc. Soc. exp. Biol. (N.Y.)109, 737 (1962).

    Google Scholar 

  8. Rohmer, P., U. Sanders, andN. Bezssonoff: Synthesis of vitamin C by the infant. Nature (Lond.)134, 142 (1934).

    Google Scholar 

  9. Rohmer, P., etN. Bezssonoff: La synthèse de la vitamine C chez le nourrisson humain. Z. Vitaminforsch.12, 104 (1942).

    Google Scholar 

  10. Salomon, L. L., andD. W. Stubbs: Restoration of aldonolactonase activity by somatotropin in hypophysectomized rats. Biochem. biophys. Res. Commun.5, 349 (1961).

    Google Scholar 

  11. Jackel, S. S., E. H. Mosbach, andC. G. King: Ion exchange separation of ascorbic acid and isolation of the 2,4-dinitrophenylosazone. Arch. Biochem.31, 442 (1951).

    PubMed  Google Scholar 

  12. Smiley, J. D., andG. Ashwell: Purification and properties of β-l-hydroxy acid dehydrogenase. II. Isolation of β-keto-l-gulonic acid, an intermediate inl-xylulose biosynthesis. J. biol. Chem.236, 357 (1961).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Durchgeführt mit Unterstützung derResearch Corporation, New York.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hollmann, S., Neubaur, J. Zur Frage der Ascorbinsäure-Synthese in der Leber des menschlichen Feten und Frühgeborenen. Klin Wochenschr 44, 722–723 (1966). https://doi.org/10.1007/BF01790800

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01790800

Navigation