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Experimental cerebral vasospasm: Resolution by iloprost

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Summary

A new stable analogue of prostacyclin, iloprost, was tested on the basilar artery of anaesthetized rabbits constricted by electrical stimulation and intracisternal injection of autologous blood. The vasospasm induced by these stimuli was effectively relieved (about 100%) by topical application of iloprost, a stable analogue of prostacyclin (PGI2), and no constriction occurred on further stimulation within one hour. The mechanisms of the action of iloprost and its possible therapeutic value in subarachnoid haemorrhage are discussed.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Ankara, Turkey

    R. K. Türker

  2. Department of Neurosurgery, University of Ankara, Turkey

    N. Egemen, K. Birler & N. Avman

Authors
  1. N. Egemen
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  2. K. Birler
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  3. N. Avman
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  4. R. K. Türker
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Additional information

Prof. Dr. N. Avman, Chairman of the Department of Neurosurgery, Faculty of Medicine, Ankara University, suddenly died on February 20, 1988 following an acute cardiac infarct.

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Egemen, N., Birler, K., Avman, N. et al. Experimental cerebral vasospasm: Resolution by iloprost. Acta neurochir 95, 131–135 (1988). https://doi.org/10.1007/BF01790774

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