Cancer Immunology, Immunotherapy

, Volume 31, Issue 4, pp 250–254 | Cite as

Common variable immunodeficiency and malignancy: a report of two cases and possible explanation for the association

  • Igor Vorechovsky
  • Jiri Litzman
  • Jindrich Lokaj
  • Petr Hausner
  • Tomas Poch
Original articles

Summary

Two patients with common variable immunodeficiency (CVID) and malignant tumours are reported. The first patient developed myelogenous leukaemia soon after the myelodysplastic syndrome has been diagnosed. The undifferentiated gastric lymphoma found in the second patient suggests that an increased risk of gastrointestinal malignancies in CVID could partly be due to lymphomas. We hypothesize that the tissue- or site-specific risk of lymphomas and gastrointestinal cancer can be explained by an increased chromosomal or genomic instability with a higher mutation rate and genomic disorganization, and that this instability could be related to viral carcinogenesis. The primary immunodeficiency per se may not be responsible for the cancer susceptibility in CVID patients.

Keywords

Lymphoma Cancer Research Malignant Tumour Mutation Rate Myelodysplastic Syndrome 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Igor Vorechovsky
    • 1
  • Jiri Litzman
    • 2
  • Jindrich Lokaj
    • 2
  • Petr Hausner
    • 3
  • Tomas Poch
    • 4
  1. 1.Paediatric Research InstituteBrnoCzechoslovakia
  2. 2.Department of Clinical ImmunologyFaculty HospitalBrnoCzechoslovakia
  3. 3.Oncological Research LaboratoryFaculty of General MedicinePraha 2Czechoslovakia
  4. 4.1st. Medical ClinicFaculty of General MedicinePraha 2Czechoslovakia

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