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Inhibition of dark repair of ultraviolet damage in DNA by caffeine and 8-chlorocaffeine. Kinetics of inhibition

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Summary

The inhibition of dark repair by caffeine and 8-chlorocaffeine was investigated by a cellular enzyme kinetics system. The results suggest that the caffeine and 8-chlorocaffeine act by inhibiting the excision enzyme of the dark repair system.

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Author notes

  1. Judith Rae Lumb

    Present address: Department of Medical Microbiology, Stanford University, Stanford, California

  2. Aris S. Sideropoulos

    Present address: Palo Alto Medical Research Foundation, Palo Alto, California

  3. Delbert M. Shankel

    Present address: N.I.H. Postdoctoral Fellow (Grant No. 6-F3-CA-37, 170-01A1), M.R.C. Mutagenesis Research Unit, University of Edinburgh, Scotland

Authors and Affiliations

  1. Department of Microbiology, The University of Kansas, Lawrence, Kansas

    Judith Rae Lumb, Aris S. Sideropoulos & Delbert M. Shankel

  2. M.R.C. Mutagenesis Unit, University of Edinburgh, West Mains Road, Edinburgh, 9, Scotland

    Delbert M. Shankel

Authors
  1. Judith Rae Lumb
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  2. Aris S. Sideropoulos
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  3. Delbert M. Shankel
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Additional information

Communicated byCh. Auerbach

This work was supported by National Insitutes of Health Research Grant AI-05340, the University of Kansas Research Fund, and N.I.H. Training Grant 5 T1 GM-73.

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Lumb, J.R., Sideropoulos, A.S. & Shankel, D.M. Inhibition of dark repair of ultraviolet damage in DNA by caffeine and 8-chlorocaffeine. Kinetics of inhibition. Molec. Gen. Genet. 102, 108–111 (1968). https://doi.org/10.1007/BF01789137

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  • DOI: https://doi.org/10.1007/BF01789137

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