Summary
Ten antibiotic resistance mutants inBacillus subtilis have been tested forin vitro resistance in cell-free amino acid incorporating systems. Seven of these mutants,str-1, ole-2, spc-2, mic-1, bry-2, nea-1, andlin-2 are shown to have alterations in ribosomal function.neo-2, kan-2 andery-1 did not showin vitro alterations. Extensive cross-resistance and some cross-sensitivity to ribosomal antibiotics are determined by these mutations.
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Communicated by M. Nomura
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Goldthwaite, C., Smith, I. Physiological characterization of antibiotic resistant mutants ofBacillus subtilis . Molec. Gen. Genet. 114, 190–204 (1972). https://doi.org/10.1007/BF01788888
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DOI: https://doi.org/10.1007/BF01788888