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The SERCA3-type of organellar Ca2+pumps

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Bioscience Reports

Abstract

Of all the SERCA pumps, SERCA3 was the latest to be described and the least well known. Its primary structure deviates more than usual from the other members of the SERCA family. It is not known whether its remarkably low affinity for Ca2+ (K0.5 > 1μM) observed upon expression in the COS cell system occurs also in its normal cellular context. SERCA3 is particularly expressed at high levels in different types of blood cells and related cells like platelets, lymphocytes, mast cells and arterial endothelial cells. It is also found in cerebellar Purkinje neurons. The physiological significance of this expression pattern remains unknown.

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Abbreviations

SERCA:

Sarcoplasmic or endoplasmic reticulum Ca-ATPase

RT-PCR:

reverse transcriptase polymerase chain reaction

E-P:

the covalently phosphorylated enzyme-intermediate of the Ca2+ ATPase reaction cycle.

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Authors and Affiliations

  1. Laboratorium voor Fysiologie, KULeuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium

    Frank Wuytack, Leonard Dode, Fouzia Baba-Aissa & Luc Raeymaekers

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  1. Frank Wuytack
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  2. Leonard Dode
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  3. Fouzia Baba-Aissa
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  4. Luc Raeymaekers
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Wuytack, F., Dode, L., Baba-Aissa, F. et al. The SERCA3-type of organellar Ca2+pumps. Biosci Rep 15, 299–306 (1995). https://doi.org/10.1007/BF01788362

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  • DOI: https://doi.org/10.1007/BF01788362

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