, Volume 40, Issue 1, pp 427–433 | Cite as

The sex ratio in spina bifida

  • J. Timson


It is shown that the well known excess of females in spina bifida children is statistically significant when they are compared with (a) the general population and (b) their sibs.

Although there is a small excess of males amongst the sibs this is not statistically significant when compared with the general population and when all the children in these families are considered they appear to have a sex ratio very similar to that general population. The sibs of the parents of spina bifida children show a statistically significant excess of females.

These findings are discussed with particular reference to the genetics of spina bifida.


General Population Spina Bifida Significant Excess Small Excess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Carter, C. O., P. A. David &K. M. Laurence (1968). A family study of major central nervous system malformations in South Wales.J. Med. Genet. 5: 81.PubMedGoogle Scholar
  2. Collmann, R. D. &A. Stoller, (1962). Epidemiology of congenital anomalies of the central nervous system with special reference to patterns in the state of Victoria, Australia.J. Ment. Defic. Res. 6: 22.Google Scholar
  3. Doran, P. A. &A. N. Guthkelch (1961). Studies in spina bifida cystica, 1. General survey and reassessment of the problem.J. Neurol. Neurosurg. Psychiat. 24: 331.PubMedGoogle Scholar
  4. MacMahon, B., T. F. Pugh &T. H. Ingalls (1953). Anencephelus, spina bifida and hydrocephalus; incidence related to sex, race and season of birth and incidence in siblings.Brit. J. prev. soc. Med. 7: 211.Google Scholar
  5. Polman, A. (1950). Anencephaly, spina bifida and hydrocephaly.Genetica 25: 29.Google Scholar
  6. Record, R. G. &T. McKeown (1949). Congenital malformations of the central nervous system 1. A survey of 930 cases.Brit. J. prev. soc. Med. 3: 183.Google Scholar
  7. Registrar General (1953). Decennial supplement. England and Wales, 1931, Part II B. H. M. S. O., London.Google Scholar
  8. Registrar General (1968). Statistical Review of England and Wales for 1966. Part II. H. M. S. O., London.Google Scholar
  9. Smithells, R. W. &E. R. Chinn (1965). Spina bifida in Liverpool.Develop. Med. Child. Neurol. 7: 258.Google Scholar
  10. Williamson, E. M. (1965). Incidence and family aggregation of major congenital malformations of the central nervous system.J. Med. Genet. 2: 161.Google Scholar

Copyright information

© Martinus Nijhoff 1969

Authors and Affiliations

  • J. Timson
    • 1
  1. 1.Department of Medical GeneticsThe Royal InfirmaryEngland

Personalised recommendations