Skip to main content

Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan

Clinical & Experimental Metastasis volume 6, pages 115–120 (1988)Cite this article

Abstract

Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Ashwell, G., andMorell, A. G., 1974, The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins.Advances in Enzymology,41, 99–128.

    Google Scholar 

  2. Baenziger, J. E., 1985, The role of glycosylation by protein recognition.American Journal of Pathology,121, 382–391.

    PubMed  Google Scholar 

  3. Beuth, J., andUhlenbruck, G., 1985, Leber-Lektine als Mediatoren der Metastasierung maligner Tumoren.Zeitschrift für funktionelle Biologie und Medizin,5, 269–275.

    Google Scholar 

  4. Beuth, J., Oette, K., andUhlenbruck, G., 1986, Liver lectins as receptors for tumor cells in metastasis.Lectins, Vol. 5, edited by D. van Driesche and T. C. Bog-Hansen (Berlin: Walter de Gruyter), pp. 229–237.

    Google Scholar 

  5. Beuth, J., Ko, H. L., Oette, K., Pulverer, G., Roszkowski, K., andUhlenbruck, G., 1987, Inhibition of liver metastasis in mice by blocking of hepatocyte lectins with arabinogalactan infusions andd-galactose.Journal of Cancer Research and Clinical Oncology,113, 51–55.

    PubMed  Google Scholar 

  6. Beuth, J., Ko, H. L., Schroten, H., Sölter, J., Uhlenbruck, G., andPulverer, G., 1987, Lectin mediated adhesion ofStreptococcus pneumoniae and its specific inhibitionin vitro andin vivo.Zentralblall für Bakteriologie,265, 160–168.

    Google Scholar 

  7. Cheingsong-Popov, R., Robinson, P., Altevogt, P., andSchirrmacher, V., 1983, A mouse hepatocyte carbohydrate-specific receptor and its interaction with liver-metastasizing tumor cells.International Journal of Cancer,32, 359–366.

    Google Scholar 

  8. Collard, J. G., Schijven, J. F., Bikker, A., La Riviere, G., Bolscher, J. G. M., andRoos, E., 1986, Cell surface sialic acid and the invasive and metastatic potential of T-cell hybridomas.Cancer Research,46, 3521–3527.

    Google Scholar 

  9. Fidler, I. J., 1985, Macrophages and metastasis—a biological approach to cancer therapy.Cancer Research,45, 4714–4726.

    PubMed  Google Scholar 

  10. Fidler, I. J., andPoste, G., 1982, Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease.Springer Seminars Immunopathology,5, 161–174.

    Google Scholar 

  11. Gabius, H. J., Engelhardt, R., andCramer, F., 1986, Endogenous tumor lectins: a new class of tumor markers and target for therapy.Medical Hypothesis,18, 47–53.

    Google Scholar 

  12. Gabius, H. J.,Bandlow, G.,Schirrmacher, V.,Nagel, G. A., andVehmeyer, K., 1987, Differential expression of endogenous sugar-binding proteins (lectins) in murine tumor model systems with metastatic capacity.International Journal of Cancer (in the press).

  13. Hakomori, S. J., 1985, Aberrant glycosylation in cancer cell membranes as focussed on glycolipids: overview and perspectives.Cancer Research,45, 2405–2414.

    PubMed  Google Scholar 

  14. Liotta, L. A., Kleinerman, J., andSaidel, G. M., 1976, The significance of hematogeneous tumor cell clumps in the metastatic process.Cancer Research,36, 889–894.

    PubMed  Google Scholar 

  15. Raz, A., Meromsky, L., andLotan, R., 1986, Differential expression of endogenous lectins on the surface of non tumorigenic, tumorigenic and metastatic cells.Cancer Research,46, 3667–3672.

    PubMed  Google Scholar 

  16. Roszkowski, K., Ko, H. L., Roszkowski, W., Jeljaszewicz, J., andPulverer, G., 1985, Effect of some antimicrobial antibiotics on sarcoma L-1 tumor growth in mice.Zentralblatt für Bakteriologie, Suppl. 13, 199–213.

    Google Scholar 

  17. Schirrmacher, V., Shantz, G., Clauer, K., Kamitowski, D., Zimmermann, H. P., andLohmann-Matthes, M. L., 1979, Tumor metastases and cell mediated immunity in a model system in DBA/2 mice. I. Tumor invasivenessin vitro and metastasis formationin vivo.International Journal of Cancer,23, 233–238.

    Google Scholar 

  18. Schirrmacher, V., Cheingsong-Popov, R., andArnheiter, H., 1980, Hepatocyte-tumor cell interactionin vitro. I. Conditions for rosette formation and inhibition by anti-H-2 antibody.Journal of Experimental Medicine,151, 984–989.

    PubMed  Google Scholar 

  19. Schirrmacher, V., Altevogt, P., Fogel, M., Dennis, J., Waller, C. A., Barz, D., Schwartz, R., Cheingsong-Popov, R., Springer, G., Robinson, P. J., Nebe, T., Brossmer, W., Vlodavsky, J., Paweletz, N., Zimmermann, H. P., andUhlenbruck, G., 1982, Importance of cell surface carbohydrates in cancer cell adhesion, invasion and metastasis. Does sialic acid direct metastatic behaviour?Invasion Metastasis,2, 313–360.

    Google Scholar 

  20. Schirrmacher, V., 1984, Tumor cell properties of importance for metastasis.Verhandlungen der Deutschen Gesellschaft für Pathologie,68, 12–17.

    Google Scholar 

  21. Schlepper-Schäfer, J., Friedrich, E., andKolb, H., 1981, Galactosyl-specific receptor on liver cells: binding sites for tumor cells.European Journal of Cell Biology,25, 95–102.

    PubMed  Google Scholar 

  22. Sharon, N., 1986, Bacterial lectins.The Lectins, edited by E. Liemer, N. Sharon and I. J. Goldsteine (New York: Academic Press), pp. 494–522.

    Google Scholar 

  23. Sharon, N., 1984, Lectin-like bacterial adherence to animal cells.Attachment of Organisms to the Gut Mucosa, Vol. 1, edited by E. C. Baedecker (Boca Raton, Florida: CRC Press), pp. 129–147.

    Google Scholar 

  24. Springer, G. F., Cheingsong-Popov, R., Schirrmacher, V., Desai, P. R., andTegtmeyer, H., 1983, Proposed molecular basis of murine tumor cell-hepatocyte interaction.Journan of Biological Chemistry,258, 5702–5706.

    Google Scholar 

  25. Springer, G. F., Desai, P. R., Tegtmeyer, H., Schirrmacher, V., andCheingsong-Popov, R., 1983, Murine lymphoma cells possess blood group Tn-, T-, N-, M- and S-active substances.Naturwissenschaften,70, 98–99.

    PubMed  Google Scholar 

  26. Uhlenbruck, G., Wintzer, G., Kania, J., andKoch, O., 1979, Immunologische and klinisch-diagnostische Studien an tumor-assoziierten Antigenen.Forschungsberichte des Landes NRW, Nr. 2903 (Opladen: Westdeutscher Verlag).

    Google Scholar 

  27. Uhlenbruck, G., 1981, The Thomsen-Friedenreich (TF) receptor: an old history with new mystery.Immunological Communications,10, 251–264.

    PubMed  Google Scholar 

  28. Uhlenbruck, G., Beuth, J., andWeidtman, V., 1983, Liver lectins: mediators for metastasis?Experientia,39, 1314–1315.

    PubMed  Google Scholar 

  29. Uhlenbruck, G., Beuth, J., Oette, K., Schotten, T., Ko, H. L., Roszkowski, K., Roszkowski, W., Lütticken, R., andPulverer, G., 1986, Lektine und die Organotropie der Metastasierung.Deutsche Medizinische Wochenschrift,111, 991–995.

    PubMed  Google Scholar 

  30. Uhlenbruck, G., Beuth, J., Oette, K., Roszkowski, W., Ko, H. L., andPulverer, G., 1986, Prevention of experimental liver metastases by arabinogalactan.Naturwissenschaften. 73, 626–627.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Hygiene, University of Cologne, D-5000, Cologne 41, F.R. Germany

    J. Beuth, H. L. Ko & G. Pulverer

  2. Deutsches Krebsforschungszentrum, D-6900, Heidelberg, F.R. Germany

    V. Schirrmacher

  3. Department of Immunobiology, Medical University Clinic I, D-5000, Cologne 41, F.R. Germany

    G. Uhlenbruck

Authors
  1. J. Beuth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. L. Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Schirrmacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Uhlenbruck
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Pulverer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beuth, J., Ko, H.L., Schirrmacher, V. et al. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Clin Exp Metast 6, 115–120 (1988). https://doi.org/10.1007/BF01784842

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01784842

Keywords

  • Public Health
  • Tumor Cell
  • Lymphoma
  • Cancer Research
  • Sarcoma