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A comparative study of myocardial infarct detection using Tc99m pyrophosphate and In111 DTPA antimyosin (R11D10 Fab)

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Summary

A crossover study to examine the potential of In111 antimyosin Fab fragment to detect fresh myocardial infarcts in comparison with Tc99m pyrophosphate is reported. In 27 cases indium antimyosin correctly diagnosed 19 patients with infarcts and 4 true negatives. There were also 2 false positive and 2 false negative scintigrams. Tc99m pyrophosphate detected 21 infarcts and 6 true negatives correctly.

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References

  1. Khaw BA, Beller GA, Haber E: Experimental myocardial infarct imaging following intravenous administration of iodine-131 labelled antibody fragments specific for cardiac myosin. Circulation 1978; 57: 743.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Dr Daniel den Hoed Clinic, Groene Hilledijk 301, 3075, EA Rotterdam, The Netherlands

    Peter H. Cox & Marrimuthoo Pillay

  2. The Stichting Streek Ziekenhuis Hilversum, The Netherlands

    Dirk Schonfeld

  3. Dept of Cardiology, Zuiderziekenhuis, Rotterdam, The Netherlands

    Willem F. Remme & Ritzo Brons

Authors
  1. Peter H. Cox
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  2. Dirk Schonfeld
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  3. Willem F. Remme
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  4. Marrimuthoo Pillay
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  5. Ritzo Brons
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Cox, P.H., Schonfeld, D., Remme, W.F. et al. A comparative study of myocardial infarct detection using Tc99m pyrophosphate and In111 DTPA antimyosin (R11D10 Fab). Int J Cardiac Imag 2, 197–198 (1987). https://doi.org/10.1007/BF01784307

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  • DOI: https://doi.org/10.1007/BF01784307

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