Neurosurgical Review

, Volume 10, Issue 3, pp 191–196 | Cite as

123I-amphetamine-SPECT in classical migraine and migraine accompagnée

  • Hans-Peter Schlake
  • Karl-Heinz Grotemeyer
  • Ingolf Böttger
  • Ingo Wilhelm Husstedt
  • Günter Brune
Original articles


Migraine is considered to be a functional neurological disorder. In classical migraine (headache associated with prodromal visual field disturbances) and migraine accompagnée (headache associated with transient neurological symptoms), disturbances of cerebral blood flow and amine metabolism are thought to be pathogenetic factors. However, conventional methods of neuroimaging (CAT, NMR) usually do not yield any pathological findings in patients.

Since123I-iodoamphetamine (123I-IMP) crosses the intact blood brain barrier,123I-IMP-SPECT is used for the assessment of cerebral perfusion in various neurological diseases, including functional disorders.

123I-IMP-SPECT was performed on 5 patients with classical migraine and 18 patients with migraine accompagnée. At the time of investigation, all patients were symptom-free.

Cerebral blood flow was decreased in all patients with migraine accompagnée, and often corresponded to the site of headache as well as to the topography of transient neurological symptoms. This reduction was most obvious in a patient with persisting neurological symptoms. Most patients with classical migraine, however, did not show any alteration of cerebral perfusion.

It appears that migraine — and in particular migraine accompagnée — is characterized by a permanent alteration not only of cerebral blood flow but also of neuronal activity. Migraine attacks may occur in connection with exacerbations of preexisting metabolic alterations.


Cerebral perfusion migraine SPECT 


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Copyright information

© Walter de Gruyter & Co. 1987

Authors and Affiliations

  • Hans-Peter Schlake
    • 1
  • Karl-Heinz Grotemeyer
    • 1
  • Ingolf Böttger
    • 2
  • Ingo Wilhelm Husstedt
    • 1
  • Günter Brune
    • 1
    • 3
  1. 1.Department of NeurologyUniversity HospitalMünsterWest Germany
  2. 2.Institute of Nuclear MedicineWestfälische Wilhelms-UniversitätMünsterWest Germany
  3. 3.Neurologische Klinik und PoliklinikMünsterWest Germany

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