, Volume 24, Issue 3, pp 263–266 | Cite as

Fluconazole inCandida albicans sepsis during pregnancy: Case report and review of the literature

  • E. C. Wiesinger
  • C. Wenisch
  • S. Breyer
  • W. Graninger
  • Sylvia Mayerhofer
Case Report


Candida sepsis during pregnancy is a rare but life-threatening complication of infection withCandida albicans. In contrast to the situation with other antimicrobial agents, there exists only limited experience with systemic antifungal therapy during pregnancy. A recent report focuses on amphotericin B treatment in systemic fungal infection during pregnancy. The present report discusses a pregnant patient withCandida albicans sepsis and endophthalmitis as well as candida infection of the oral and genital mucous membranes, after hyperalimentation and broad spectrum antibiotic therapy via a central venous catheter. The patient was treated with 10 mg/kg fluconazole from week 16 of gestation for a total duration of 50 days. Adverse effects did not occur and the rest of the pregnancy proceeded favourably for both the mother and the baby.


Candida Amphotericin Fluconazol Central Venous Catheter Mucous Membrane 
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Therapie einer Candidasepsis mit Fluconazol während Schwangerschaft: Fallbericht und Literaturübersicht


Eine Candidasepsis während der Schwangerschaft gehört zu den seltenen aber lebensbedrohlichen Infektionen mit diesem Keim. Im Gegensatz zu den meisten Antibiotika gibt es nur geringe Erfahrung in der antimykotischen Therapie bei dieser Erkrankung. Jüngst erst wurde eine Arbeit über Therapie mit Amphotericin B in der Schwangerschaft publiziert. In unserem Fallbericht diskutieren wir eine Patientin, die im Anschluß an eine Therapie mit Breitspektrum-Antibiotika und zentralvenöser parenteraler Ernährung eine Candidasepsis mit Endophthalmitis und oraler sowie genitaler Schleimhautbeteiligung erlitt. Wir behandelten mit 10 mg/kg Fluconazol ab der 16. Schwangerschaftswoche über insgesamt 50 Tage. Es traten keine Nebenwirkungen auf und die weitere Schwangerschaft verlief für Mutter und Kind komplikationslos.


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Copyright information

© MMV Medizin Verlag GmbH München 1996

Authors and Affiliations

  • E. C. Wiesinger
    • 1
  • C. Wenisch
    • 1
  • S. Breyer
    • 1
  • W. Graninger
    • 1
  • Sylvia Mayerhofer
    • 2
  1. 1.Dept. of Internal Medicine IDiv. of Infectious Diseases and ChemotherapyAustria
  2. 2.Div. of Immunology, Allergy and Infectious Diseases, Dept. of DermatologyUniversity of Vienna, Medical SchoolViennaAustria

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