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Die Kombinationswirkung von Cephacetril mit Gentamicin, Amikacin, Sisomicin und Tobramycin bei Enterokokken, Escherichia coli, Indol-positiven Proteus-Stämmen und Klebsiellen

Effectiveness of cephacetrile in combination with gentamicin, amikacin, sisomicin and tobramycin against enterococci, escherichia coli, indole-positive proteus species and klebsiella

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Zusammenfassung

Bei je 20 Klebsiella pneumoniae- (verschiedene K-Typen), E. coli- (verschiedene O-Typen), Indolpositiven Proteus- und Enterokokken-Stämmen wurde die Wirkung von Cephacetril in Kombination mit vier Aminoglykosiden (Gentamicin, Amikacin, Sisomicin, Tobramycin) mittels der “checkerboard dilution technique” getestet. 68% der Stämme reagierten indifferent, 16% wurden additiv, weitere 16% partiell synergistisch oder synergistisch (insgesamt 5,4%) gehemmt. Nur bei 0,4% aller Stämme trat Antagonismus auf. Die Kombination Cephacetril-Gentamicin war jeweils der mit Amikacin, Sisomicin und Tobramycin leicht überlegen. Proteus-Stämme wurden eher als Klebsiella und E. coli von den Cephacetril-Aminoglykosid Kombinationen additiv, partiell synergistisch bzw. synergistisch beeinflußt. Bei 56% der Enterokokken-Stämme trat ein additiver oder partiell synergistischer Effekt auf.

Summary

The effect of cephacetrile in combination with four aminoglycosides (gentamicin, amikacin, sisomicin, tobramycin) was tested by means of the checkerboard dilution technique with 20 strains each of Klebsiella pneumoniae (various K-types), E. coli (various O-types), indole-positive Proteus and enterococci. 68% of the strains reacted indifferently; in 16% an additive inhibitory effect was observed, and in a further 16% a partially synergistic or synergistic (5.4%) inhibition was observed. Antagonism occurred in only 0.4% of all strains. The combination of cephacetrile-gentamicin was slightly superior to the combination with amikacin, sisomicin and tobramycin respectively. The cephacetrile-aminoglycoside combination had a greater additive, partially synergistic or synergistic effect on Proteus strains than on Klebsiella and E. coli. In 56% of the enterococci strains, an additive or partially synergistic effect was observed.

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  1. Leiter der Klinikhygiene der Universitätskliniken, Hugstetter Straße 55, 7800, Freiburg

    F. Daschner

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  1. F. Daschner
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Daschner, F. Die Kombinationswirkung von Cephacetril mit Gentamicin, Amikacin, Sisomicin und Tobramycin bei Enterokokken, Escherichia coli, Indol-positiven Proteus-Stämmen und Klebsiellen. Infection 4 (Suppl 3), S246–S255 (1976). https://doi.org/10.1007/BF01781052

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