Summary
The study is concerned with the pharmacological and clinical evaluation of cephacetrile as given by the results obtained in 23 patients with lower respiratory infections. The criteria employed comprised not only pharmacokinetic parameters such as serum and urine concentrations and the serum half-life, but also bacteriological and clinical data obtained in the course of careful examinations carried out before, during, and after treatment. The studies conducted for this purpose included various laboratory tests, as well as differential blood counts, tests of respiratory function, sputum investigations, and tests of hepatic and renal function. In the patients under review, most of whom were old (average age 62 years) and in moderate or poor condition, treatment with cephacetrile (1 g twice daily i. m.) enabled a complete clinical success to be achieved in 69 % of cases, a partial success being obtained in a further 13 %. The bacteriological and laboratory findings (e.g. improvement in the sputum characteristics) correlated well with the clinical response. Cephacetrile was well tolerated; in particular, it appeared to have no nephrotoxic properties.
Zusammenfassung
Die vorliegende Studie befaßt sich mit der pharmakologischen und klinischen Evaluierung von Cephacetril anhand von 23 Patienten mit Infektionskrankheiten des unteren Atemtrakts. Beurteilungskriterien waren, neben pharmakokinetischen Daten wie Serum- und Urinkonzentrationen sowie Serum-Halbwertszeit, sorgfältige bakteriologische und klinische Erhebungen vor, während und nach der Therapie inklusive diverse Laboruntersuchungen, Differentialblutbild, Atemfunktionstest, Sputumbefund, Leber- und Nierenfunktionstests. Bei dem vorwiegend älteren Patientengut (Durchschnittsalter 62 Jahre) mit dominant schwerem Krankheitsbild erbrachte Cephacetril, 2×1 g/die i. m. verabfolgt, in 69 % der Fälle klinische vollen therapeutischen Erfolg, in weiteren 13 % klinischen Teilerfolg. Bakteriologische Heilung und Laborbefunde (z. B. Besserung des Sputum-Befunds) zeigten gute Korrelation zu den klinischen Resultaten. Die Verträglichkeit von Cephacetril war gut, insbesondere besitzt es offensichtlich keine nephrotoxischen Eigenschaften.
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Literature
Bayley, A. J. A comparative trial of ampicillin and cephaloridine in acute chest infections. Brit. J. Dis. Chest. 64 (1970) 232–237.
Galbraith, H. J. Cephaloridine in the treatment of infections of lungs and lower respiratory tract. Postgrad. Med. J. 43 (1967) Suppl., 58–61.
Opitz, A. et al.: Treatment of chronic kidney infections with the cephalosporin derivative CIBA 36, 278-Ba. In: Advances in antimicrobial and antineoplastic chemotherapy. Progress in research and clinical application. Urban & Schwarzenberg, München-Berlin-Wien 1972.
Pines, A., Plucinski, K., Greenfield, J. S. B., Mitchell, R. C. Controlled comparison of lymecycline with tetracycline hydrochloride in exacerbations of chronic bronchitis. Brit. med. J. 2 (1964) 1495–1498.
Williams, J. D., Andrews, J. Sensitivity of haemophilus influenzae to antibiotics. Brit. med. J. 1 (1974) 134–137.
Wise, R., Reeves, D. S. Pharmacological studies on cephacetrile in human volunteers. Curr. Med. Res. Opin. 2 (1974) 249–255.
Wise, R., Reeves, D. S., Hepburn, P. R. Cephacetrile, a new cephalosporin, in the treatment of urinary tract infections. Chemotherapy 20 (1974) 177–182.
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Reeves, D.S., Thomas, A.L. Lower respiratory infections treated with cephacetrile. Infection 4 (Suppl 3), S225–S228 (1976). https://doi.org/10.1007/BF01781048
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DOI: https://doi.org/10.1007/BF01781048