Summary
An open, randomized study was carried out to compare the efficacy of ciprofloxacin, 250 mg twice daily, and ofloxacin, 200 mg twice daily, in hospitalized patients with lower respiratory tract infections such as bacterial exacerbation of chronic bronchitis or community-acquired pneumonia. Fifty patients were treated in each group. The duration of treatment was 10 to 12 days. Microbiological examinations were carried out on sputum samples taken before, during and after treatment. In both groups, the clinical results were considered to be excellent, with clinical cure in 98% of the patients treated with ciprofloxacin and in 90% of patients treated with ofloxacin. Eradication of the initial sputum isolate was achieved in 98% of the patients of the ciprofloxacin group and in 82% of the patients of the ofloxacin group.
Zusammenfassung
Zum Vergleich der Wirksamkeit von Ciprofloxacin in einer Dosis von zweimal täglich 250 mg und Ofloxacin in einer Dosis von zweimal täglich 200 mg bei Patienten mit tiefen Atemwegsinfektionen (bakterielle Exazerbation einer chronischen Bronchitis oder ambulant erworbene Pneumonie) wurde eine randomisierte, offene Studie durchgeführt. In jeder Gruppe wurden 50 Patienten 10 bis 12 Tage lang behandelt. Mikrobiologische Sputumuntersuchungen wurden vor, während und nach Abschluß der Therapie durchgeführt. Die Ergebnisse wurden bei beiden Gruppen als ausgezeichnet bewertet. Eine klinische Heilung wurde bei 98% der Patienten der Ciprofloxacin-Gruppe und bei 90% der Patienten der Ofloxacin-Gruppe erzielt. Vor Therapiebeginn aus Sputum isolierte Bakterien waren in 98% der Fälle nach Behandlung mit Ciprofloxacin und in 82% nach Behandlung mit Ofloxacin eliminiert.
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References
Andriole, V. T. The Quinolones. Academic Press, New Haven 1988, pp. 1–250.
Hooper, D. C., Wolfson, J. S., Eva, Y. N. G., Swartz, M. W. Mechanism of action and resistance to ciprofloxacin. Am. J. Med. 82 (1987) 12–20.
Lode, H. Chinolone. Schweiz. Med. Wochenschr. 118 (1988) 1829–1830.
Dzierzanowska, D., Ukraiński, W., Piotrowska, E., Kaźmirowski, Z., Pykiel, M. Ocena aktywności nowych fluoropochodnych piperazonolo-chonoliny wobec klinicznych szczepów bakterii i beztlenowych. Pol. Tyg. Lek. 41 (1986) 1180–1182.
Kahn, F. A. What role for quinolones in respiratory tract infections? J. Respir. Dis. 11 (1990) 1.
Polubiec, A., Weuta, H., Kubica, J., Starzyńska, R., Stepka, K.: Ciprofloxacin in treatment of urinary tract infections. 4th Mediterranean Congress of Chemotherapy, 19–25 October 1984, Rhodes, Abstract 629.
Polubiec, A., Busch, W., Kubica, J., Starzyńska, R., Stepka, K.: Comparison of oral ciprofloxacin with gentamycin in the treatment of pyelonephritis. 6th Mediterranean Congress of Chemotherapy, 22–27 May 1988, Taormina-Giardini, Naxos, Abstract 81.
Polubiec, A., Jórasz, I., Kłos, K., Oźarek Medyńska, T., Pietrzak, J., Starzyńska, R., Stepka, K. Wyniki leczenia ciprofloxacina zakazeń dróg moczowych i oddechowych. Pol. Tyg. Lek. 45 (1990) 85–89.
Polubiec, A., Jórasz, I., Pietrzak, J., Soszka, A., Stepka, K., Zaryn, A.: Comparison of ciprofloxacin and ofloxacin in the treatment of respiratory tract infections. 17th International Congress of Chemotherapy, 23–28 June 1991, Berlin, Abstract 1866.
Polubiec, A., Jórasz, I., Kłos, K., Oźarek Medyńska, T., Pietrzak, J., Starzyńska, R., Stepka, K.: Results of ciprofloxacin therapy in urinary and respiratory tract infections. Clinical Digest Series USA, Infectious Disease Digest — Therapy/Prevention (in press).
Wise, R. The activity of quinolones against respiratory tract pathogens. Quinolones Bull. 1 (1985) 1–2.
Polubiec, A., Weuta, H., Stepka, K., Kłos, K., Starzyńska, Jórasz, L. Bacterial infections of the lower urinary tract treated with ciprofloxacin and cephalexin. A comparative study. Infection 16 Suppl. 1 (1988) S62-S64.
Giamarellou, H., Galanakis, N., Stephanou, J., Daphis, E., Daikos, G. K. Clinical efficacy of ciprofloxacin in severe infections. Curr. Clin. Pract. Sec. 34 (1986) 420–425.
Scully, B., Parry, M. F., Neu, H. C., Mandell, W. Oral ciprofloxacin therapy of infections due toPseudomonas aeruginosa. Lancet i (1986) 819–822.
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Polubiec, A., Jórasz, I., Pietrzak, J. et al. A Randomized study comparing low dose ciprofloxacin and ofloxacin in the treatment of lower respiratory tract infections. Infection 22, 62–64 (1994). https://doi.org/10.1007/BF01780772
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DOI: https://doi.org/10.1007/BF01780772