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Inflammation Research

, Volume 44, Supplement 2, pp S179–S180 | Cite as

Sirolimus (rapamycin) inhibits mitogen-induced stimulation of protein synthesis in primary lymphocytes

  • C. C. Bansbach
  • D. Wancio
  • S. N. Sehgal
VI. Lymphocyte activation/immunoregulation

Keywords

Protein Synthesis Rapamycin Sirolimus Primary Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    Sehgal SN, Bansbach CC. Rapamycin: in vitro profile of a new immunosuppressive macrolide. Ann of NY Academy Sciences 1993;685:58–67.Google Scholar
  2. [2]
    Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992;69:1227–36.PubMedGoogle Scholar
  3. [3]
    Kuo CJ, Chung J, Florentino DF, Flanagan WM, Blenis J, Crabtree GR. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992;358:70–3.PubMedGoogle Scholar
  4. [4]
    Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 1992;257:973–7.PubMedGoogle Scholar
  5. [5]
    Terada N, Lucas JJ, Szepesi A, Franklin RA, Takase K, Gelfand EW. Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells. Biochem Biophys Res Commun 1992;186:1315–21.PubMedGoogle Scholar
  6. [6]
    Jefferies HBJ, Reinhard C, Kozma SC, Thomas G. Rapamycin selectively represses translation of the “polypyrimidine tract” mRNA family. Proc Natl Acad Sci 1994;91:4441–5.Google Scholar
  7. [7]
    Bansbach CC, Casilio-Lonardo E, Adams LM, Sehgal SN, Chang JY. Inhibition of human lymphocyte proliferation by rapamycin, a novel immunosuppressant, FASEB J 4:A1768.Google Scholar

Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • C. C. Bansbach
    • 1
  • D. Wancio
    • 1
  • S. N. Sehgal
    • 1
  1. 1.Wyeth-Ayerst ResearchPrincetonUSA

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