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Inflammation Research

, Volume 44, Supplement 2, pp S151–S152 | Cite as

Degradation of bovine cartilage proteoglycanin vitro is enhanced by inhibition of nitric oxide synthase

  • A. C. Hanglow
  • K. Rowan
  • L. Lusch
  • J. W. Coffey
III. Nitric Oxide

Keywords

Oxide Nitric Oxide Bovine Cartilage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Palmer RMJ, Hickery MS, Charles IG, Moncada S, Bayliss MT. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Comm 1993;193:398–405.PubMedGoogle Scholar
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    Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene. Biochim Biophys Acta 1986;883:173–7.PubMedGoogle Scholar
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    Buttle DJ, Handley CJ, Ilic MZ, Saklatvala J, Murata M, Barrett AJ. Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthr Rheum 1993;36:1709–17.Google Scholar
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    Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 1993;53:2087–91.PubMedGoogle Scholar
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    Taskiran D, Stefanovic-Racic M, Georgescu H, Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Comm 1994;200:142–8.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • A. C. Hanglow
    • 1
  • K. Rowan
    • 1
  • L. Lusch
    • 1
  • J. W. Coffey
    • 1
  1. 1.Department of Inflammation and Autoimmune DiseasesHoffmann-La Roche Inc.NutleyUSA

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