Inflammation Research

, Volume 44, Supplement 2, pp S151–S152 | Cite as

Degradation of bovine cartilage proteoglycanin vitro is enhanced by inhibition of nitric oxide synthase

  • A. C. Hanglow
  • K. Rowan
  • L. Lusch
  • J. W. Coffey
III. Nitric Oxide

Keywords

Oxide Nitric Oxide Bovine Cartilage 

References

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    Palmer RMJ, Hickery MS, Charles IG, Moncada S, Bayliss MT. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Comm 1993;193:398–405.PubMedGoogle Scholar
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    Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene. Biochim Biophys Acta 1986;883:173–7.PubMedGoogle Scholar
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    Buttle DJ, Handley CJ, Ilic MZ, Saklatvala J, Murata M, Barrett AJ. Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthr Rheum 1993;36:1709–17.Google Scholar
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    Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 1993;53:2087–91.PubMedGoogle Scholar
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    Taskiran D, Stefanovic-Racic M, Georgescu H, Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Comm 1994;200:142–8.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • A. C. Hanglow
    • 1
  • K. Rowan
    • 1
  • L. Lusch
    • 1
  • J. W. Coffey
    • 1
  1. 1.Department of Inflammation and Autoimmune DiseasesHoffmann-La Roche Inc.NutleyUSA

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