References
Fletcher ML, Trowell JM, Craske J, et al. (1983) Non-A, non-B hepatitis after transfusion of factor VIII in infrequently treated patients. Br Med J 287:1754–57
Kernoff PBA, Lee CA, Karayiannis P, et al. (1985) High risk of non-A, non-B hepatitis after a first exposure to volunteer or commercial clotting factor concentrates: Effects of prophylactic immune serum globulin. Br J Haematol 60:469–79
Colombo M, Mannucci PM, Carnelli V, et al. (1985) Transmission of non-A, non-B hepatitis by heat-treated factor VIII concentrate. Lancet ii:1–4
Survey of non-U.S. hemophilia treatment centers for HIV seroconversions following therapy with heat-treated concentrates. MMWR (1987) 36:121-24
Hanley JA, Lippman-Hand A (1983) If nothing goes wrong, is everything all right? JAMA 249:1743–45
Schimpf K, Mannucci PM, Kreutz W, et al. (1987) Absence of hepatitis after treatment with a pasteurized factor VIII concentrate in patients with hemophilia and no previous transfusion. N Engl J Med 316:918–22
Mannucci PM, Schimpf K, Brettler DB, et al. (1990) Low risk for hepatitis C in hemophiliacs given a high-purity, pasteurized factor VIII concentrate. Ann Int Med 113:27–32
Mannucci PM, Zanetti AR, Colombo M (1990) Antibody to hepatitis C virus after a vapour-heated factor VIII concentrate. Thromb Haemostas 64:232–34
Mannucci PM, Schimpf K, Abe T, et al. (1992) Low risk of viral infection after administration of vapor-heated factor VIII concentrate. Transfusion 32:134–38
Suomela H (1993) Inactivation of viruses in blood and plasma products. Transf Med Rev 7:42–57
Brachmann H-H, Egli H (1988) Acute hepatitis B infection after treatment with heat-inactivated factor VIII concentrate. Lancet ii:967
Schulman S, Lindgren A-C, Petrini P, Allander T (1992) Transmission of hepatitis C with pasteurized factor VIII. Lancet 340:305–6
Lusher JM, Salzman PM, the Monoclate Study Group (1990) Viral safety and inhibitor development associated with factor VIIIC ultra-purified from plasma in hemophiliacs previously unexposed to factor VIIIC concentrates. Semin Hematol 27:1–7
Garson JA, Preston FE, Makris M, et al. (1990) Detection by PCR of hepatitis C virus in factor VIII concentrates. Lancet 335:1473
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Berntorp, E. Viral safety issues: plasma-derived factor VIII. Ann Hematol 68 (Suppl 3), S35–S36 (1994). https://doi.org/10.1007/BF01774528
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DOI: https://doi.org/10.1007/BF01774528