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Inhibitor questions: plasma-derived factor VIII and recombinant factor VIII

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References

  1. Davidson CS, Epstein RD, Miller GF, Taylor FHL (1949) Hemophilia. A clinical study of forty patients. Blood 4: 97–119

    Google Scholar 

  2. Strauss HS (1969) Acquired circulating anticoagulants in hemophilia A. N Engl J Med 281:866–873

    PubMed  Google Scholar 

  3. Biggs R (1974) Jaundice and antibodies directed against factors VIII and IX in patients treated for haemophilia or Christmas disease in the United Kingdom. Br J Haematol 26: 313–329

    PubMed  Google Scholar 

  4. Brinkhous KM, Roberts HR, Weiss AE (1972) Prevalence of inhibitors in hemophilia A and B. Thromb Diath Haemorrh [Suppl 51]:315–321

    Google Scholar 

  5. Gill F (1984) The natural history of factor VIII inhibitors in patients with hemophilia A. Prog Clin Biol Res 150: 19–29

    PubMed  Google Scholar 

  6. Schwarzinger I, Papinger I, Korninger C et al. (1987) Incidence of inhibitors in patients with severe and moderate hemophilia A treated with factor VIII concentrates. Am J Hematol 24:241–245

    PubMed  Google Scholar 

  7. Rasi V, Ikkala E (1990) Haemophiliacs with factor VIII inhibitors in Finland: prevalence, incidence and outcome. Br J Haematol 76:369–371

    PubMed  Google Scholar 

  8. Ehrenforth S, Kreuz W, Scharrer I et al. (1992) Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. Lancet 339:594–598

    PubMed  Google Scholar 

  9. Addiego J, Kasper C, Abildgaard C et al. (1992) Inhibitors in factor VIII deficient hemophilia: comparison of frequency based upon treatment product. Blood80 [Suppl 1]:913a

    Google Scholar 

  10. Lusher JM (1991) Viral safety and inhibitor development associated with monoclonal antibody-purified FVIIIC. Ann Hematol 63:138–141

    PubMed  Google Scholar 

  11. Addiego JE, Gomperts E, Liu S-L (1992) Treatment of hemophilia A with a highly purified factor VIII concentrate prepared by anti-FVIII:C immunoaffinity chromatography. Thromb Haemostas 67:19–27

    Google Scholar 

  12. Peerlinck K, Arnout J, Gilles JG et al. (1993) A higher than expected incidence of factor VIII inhibitors in multitransfused haemophilia A patients treated with an intermediate purity pasteurized factor VIII concentrate. Thromb Haemostas 69: 115–118

    Google Scholar 

  13. Kaufman RJ (1991): Insight into the structure, function and biosynthesis of factor VIII through recombinant DNA technology. Ann Hematol 63:155–165

    PubMed  Google Scholar 

  14. Bray GL (1992) Current status of clinical studies of recombinant factor VIII (Recombinate) in patients with hemophilia A. Trans Med Rev 6:252–255

    Google Scholar 

  15. Schwartz R, Abildgaard CF, Aledort LM et al. (1990) Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. N Engl J Med 323:1800–1805

    PubMed  Google Scholar 

  16. Scandella D, Bray GL, Liu-Maruya S et al. (1992) Epitope specificity of anti-factor VIII antibodies in hemophilia A patients treated with recombinant factor VIII. Blood 80 [Suppl 1]: 1456a

    Google Scholar 

  17. Lusher JM, Arkin S, Abildgaard CF et al. (1993) Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. N Engl J Med 328:453–459

    PubMed  Google Scholar 

  18. Bray GL, Liu-Maruya S, Courter S et al. (1992) Two years' experience with recombinant factor VIII (Recombinate) in previously untreated patients with hemophilia A. Blood 80 [Suppl 1]:908a

    Google Scholar 

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Bray, G. Inhibitor questions: plasma-derived factor VIII and recombinant factor VIII. Ann Hematol 68 (Suppl 3), S29–S34 (1994). https://doi.org/10.1007/BF01774527

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