Klinische Wochenschrift

, Volume 66, Issue 3, pp 123–128 | Cite as

Acute and long-term effects of low-density lipoprotein apheresis on the serum concentrations of vitamins E and A

  • V. W. Armstrong
  • D. Niedmann
  • T. Eisenhauer
  • G. Janning
  • H. Wagner
  • P. Schuff-Werner
  • D. Seidel


Serum α-tocopherol and retinol concentrations were followed in four heterozygous adults and one homozygous child with familial hypercholesterolemia being treated by regular low-density lipoprotein (LDL) apheresis. Approximately 50% of plasma α-tocopherol was eliminated during a single apheresis procedure in the heterozygous adults, while a complete elimination of this vitamin along with LDLs was observed in the homozygous child. Absolute losses of α-tocopherol amounted to 13.4–22.5 mg/apheresis and are equivalent to the recommended dietary intake for 1.5 to 2 days. Despite these losses, no changes were observed either in serum α-tocopherol levels or in the ratio of α-tocopherol/total serum lipids after 12 months regular apheresis treatment. Serum retinol concentrations only showed a small decrease on apheresis, there being apparently no specific elimination of this vitamin. The absolute losses ranged from 42–422 µg/apheresis and were, therefore, much lower than the recommended dietary intake of the equivalent of 1500 µg retinol/day. It is concluded that no extra supplementation of these vitamins is required during LDL-apheresis therapy, although it may be advisable to monitor vitamin E status in patients on long-term, intensive therapy.

Key words

LDL apheresis Vitamin E Vitamin A α-Tocopherol Retinol 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • V. W. Armstrong
    • 1
  • D. Niedmann
    • 1
  • T. Eisenhauer
    • 2
  • G. Janning
    • 2
  • H. Wagner
    • 1
  • P. Schuff-Werner
    • 1
  • D. Seidel
    • 1
  1. 1.Abteilung für Klinische Chemie, Zentrum Innere MedizinUniversitätsklinikumGöttingen
  2. 2.Abteilung Nephrologie Zentrum Innere MedizinUniversitätsklinikumGöttingen

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