Abstract
Electron spin resonance (ESR) measurements after intracerebroventricular injection of a nitroxide radical were carried out in rats (n=6) that received oral idebenone for 2 weeks and in control rats (n=5), using anin vivo rapid scan ESR spectrometer. The half-life of nitroxide, which was estimated from the change in the peak height (ΔM=+1) of the ESR signals from the head, was used as a marker for the elimination of the nitroxide radical. The half-life in the rats treated with idebenone was significantly shorter than it was in the controls (p<0.05). This finding indicates that the treatment with idebenone can enhance the intracerebral-eliminating ability of the nitroxide radical.
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Yokoyama, H., Tsuchihashi, N., Ogata, T. et al. An analysis of the intracerebral ability to eliminate a nitroxide radical in the rat after administration of idebenone by anin vivo rapid scan electron spin resonance spectrometer. MAGMA 4, 247–250 (1996). https://doi.org/10.1007/BF01772013
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DOI: https://doi.org/10.1007/BF01772013