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Evaluation of five protocols for quantification of two-dimensional MR spectroscopic images

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Abstract

Five protocols were tested for quantification onin vivo two-dimensional spectroscopic imaging datasets. The datasets are duplo measurements from three individuals. The peaks forN-acetyl aspartate, creatines, and cholines were quantified. The first of the protocols is conventional integration of a selected interval around the peak. The others are various implementations of a Gauss-Newton-based least-squares time-domain fitting algorithm. Fitting a half-echo (free-induction decay curve, FID) to a full echo was compared; this was combined with or without filtering out the water signal using the Lanczos-Hankel singular-value decomposition (LHSVD). It appears that conventional integration yields consistent and accurate results in comparison to the fitting methods. The combination of LHSVD and echo fitting performs equally well; advantages and disadvantages are discussed. The protocols using FID fitting perform poorly with these experimental datasets.

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Authors and Affiliations

  1. Faculty of Applied Physics, Delft University of Technology, Delft, The Netherlands

    Ron de Beer

  2. MRI-Research, Medisch Spectrum Twente, P.O. Box 50000, 7500 KA, Enschede, The Netherlands

    Anton R. Peters

Authors
  1. Anton R. Peters
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  2. Ron de Beer
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Peters, A.R., de Beer, R. Evaluation of five protocols for quantification of two-dimensional MR spectroscopic images. MAGMA 3, 157–161 (1995). https://doi.org/10.1007/BF01771701

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