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Antikörperpopulationen im heterologen Antilymphocytenserum des Kaninchens

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Zusammenfassung

Im heterologen Anti-Mäuse- bzw.-Rattenlymphocytenserum von Kaninchen ließen sich die folgenden Antikörpertypen differenzieren:

  1. 1

    Anti-Erythrocyten/Leukocyten/Thrombocyten/Leber/Nierenantikörper.

  2. 2

    Anti-Leukocyten/Thrombocyten/Leber/Nierenantikörper.

  3. 3

    Anti-Leukocytenantikörper.

  4. 4

    Anti-Erythrocytenantikörper.

  5. 5

    Anti-Serumproteinantikörper.

Während anti-erythrocytäre und anti-leukocytäre Antikörper sowohl in der 7 S als auch in der 19 S Fraktion auftraten, wurden Antikörper, die gegen ein den Erythrocyten und Leukocyten gemeinsames Antigen gerichtet sind, nur in der 7 S-Fraktion nachgewiesen. Die Bedeutung des letzteren Antikörpertyps, insbesondere für die Absorption der Erythrocytenagglutine wird diskutiert.

Neben dem Fehlen der Gruppenspezifität wird gezeigt, daß die Kreuzreaktion mit Rattenblutzellen auf einen Teil der Antikörper beschränkt ist.

Summary

5 different antibody specificities can be differentiated in heterologous antilymphocytic antiserum of the rabbit:

  1. 1

    anti-erythrocyte/leukocyte/thrombocyte/liver/kidney antibody.

  2. 2

    anti-leukocyte/thrombocyte/liver/kidney antibody.

  3. 3

    anti-leukocyte antibody.

  4. 4

    anti-erythrocyte antibody.

  5. 5

    anti-serumprotein antibody.

Anti-erythrocyte and anti-leukocyte antibodies were found in the 19 S and 7 S globulin fraction, whereas antibodies directed against an antigen common to erythrocytes and leukocytes could only be demonstrated in the 7 S fraction. The practical implications of this latter type of antibody were discussed. No blood group specificity was demonstrated. The crossreactivity of anti mousecell antibodies with blood cells of the rat did not include all the antibodies in the antiserum.

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Literatur

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Authors and Affiliations

  1. Institut für Hämatologie der GSF, Assoziation Euratom, München

    S. Thierfelder, D. Möller, M. Eulitz, P. Dörmer & I. Kimura

Authors
  1. S. Thierfelder
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  2. D. Möller
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  3. M. Eulitz
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  4. P. Dörmer
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  5. I. Kimura
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Additional information

Studie im Rahmen der Assoziation Hämatologie Euratom-GSF.

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Thierfelder, S., Möller, D., Eulitz, M. et al. Antikörperpopulationen im heterologen Antilymphocytenserum des Kaninchens. Klin Wochenschr 46, 277–278 (1968). https://doi.org/10.1007/BF01770888

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  • DOI: https://doi.org/10.1007/BF01770888

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