, Volume 1, Issue 3–4, pp 176–184 | Cite as

The effect of temperature on MR relaxation times and signal intensities for human tissues

  • marianne Petrén-mallmin
  • Anders Ericsson
  • Wolfgang Rauschning
  • Anders Hemmingsson


T1 andT2 relaxation times were measured on human tissue samples of adipose tissue, muscle, bone marrow and osteolytic skeletal metastases at temperatures ranging from +37°C to −10°C. Relative signal intensities forT1, proton density andT2-weighted imaging sequences were also calculated.T1 andT2 of adipose tissue decreased almost linearly with decreasing temperature while for muscle, bone marrow and metastasesT1 andT2 decreased slightly to moderately, with temperature reduction to about −5 °C at which temperature a sudden marked decrease occurred. Calculated signal intensities showed a decrease in image contrast with temperature reduction and reversal of contrast between adipose tissue and the other tested tissues with all imaging sequences at temperatures around 0°C.


mr imaging human tissues tissue temperature mr relaxation time changes mr signal intensity changes 


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  1. 1.
    Bo, WJ, Wolf man, NT, Krueger, WA and Meschan, I (1990)Basic atlas of sectional anatomy with correlated imaging Philadelphia: WB Saunders Company.Google Scholar
  2. 2.
    Daniels, DL, Haughton, VM and Naidich, TP (1987)Cranial and spinal magnetic resonance imaging New York: Raven Press.Google Scholar
  3. 3.
    Mark, L, Pech, P, Daniels, D, Charles, C, Williams, A and Haughton, V (1984) The Pituitary fossa: A correlative anatomic and MR study.Radiology 153 453–457.PubMedGoogle Scholar
  4. 4.
    Middleton, WD and Lawson, TL (1989)Anatomy and MRI of the joints New York: Raven Press.Google Scholar
  5. 5.
    Rauschning, W, Bergström, K and Pech, P. (1983) Correlative craniospinal anatomy studies by computed tomography and cryomicrotomy.J Comput Assist Tomogr 7 9–13.PubMedGoogle Scholar
  6. 6.
    Aguila, LA, Piraino, DW, Modic, MT, Dudley, AW, Duchesneau, PM and Weinstein, MA (1985) The intranuclear cleft of the intervertebral disk: Magnetic resonance imaging.Radiology 155 155–158.PubMedGoogle Scholar
  7. 7.
    Daniels, DL, Hyde, JS, Kneeland, JB, Jesmanowicz, A, Froncisz, W, Grist, TM, Pech, P, Williams, AL and Haughton, VM (1985) The cervical nerves and foramina: Local-coil MR imaging.AJNR 7 129–133.Google Scholar
  8. 8.
    Duvernoy, O, Larsson, S-G, Thurén, J and Rauschning, W (1992) Epicardial fat causing pitfalls in CT and MR imaging of the pericardium.Acta Radiol. 33 1–5.PubMedGoogle Scholar
  9. 9.
    Flannigan, BD, Lufkin, RB, McGlade, C, Winter, J, Batzdorf, U, Wilson, G, Rauschning, W and Bradley, JWG (1987) MR imaging of the cervical spine: Neurovascular anatomy.AJR 148 785–790.PubMedGoogle Scholar
  10. 10.
    Reicher, MA, Gold, RH, Halbach, W, Rauschning, W, Wilson, GH and Lufkin, RB (1986) MR imaging of the lumbar spine: Anatomic correlations and the effect of technical variations.AJR 147 891–898.PubMedGoogle Scholar
  11. 11.
    Braffman, BH, Zimmerman, RA, Trojanowski, JQ, Gonatas, NK, Hickey, WF and Schlaepfer, WW (1988) Brain MR: Pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces.AJR 151 551–558.PubMedGoogle Scholar
  12. 12.
    Petrén-Mallmin, M, Nordström, B, Andréasson, I, Nyman, R, Jónsson, Jr, H, Rauschning, W and Hemmingsson, A. (1992) MR imaging with histopathologic correlation in vertebral metastases of breast cancer.Ada Radiol. 33 213–220.Google Scholar
  13. 13.
    Reicher, MA, Rauschning, W, Gold, RH, Basset, LW, Lufkin, RB and Glen, JW (1985) High- resolution magnetic resonance imaging of the knee joint: Normal anatomy.AJR 145 895–902.PubMedGoogle Scholar
  14. 14.
    Tovi, M, Hartman, M, Lilja, A and Ericsson, A (1994) MR imaging in cerebral gliomas. Tissue component analysis in correlation with histopathology of whole-brain specimens. Acta Radiol. 35 (in press).Google Scholar
  15. 15.
    Yu, S, Sether, L and Haughton, VM (1987) Facet joint menisci of the cervical spine: Correlative MR imaging and cryomicrotomy study.Radiology 164 79–82.PubMedGoogle Scholar
  16. 16.
    Sperber, GO, Ericsson, A, Hemmingsson, A, Jung, B and Thuomas, K-Å (1986) Improved formulae for signal amplitudes in repeated NMR sequences: Applications in NMR imaging.Magn Reson Med 3 685–698.PubMedGoogle Scholar
  17. 17.
    Rauschning, W (1983) Computed tomography and cryomicrotomy of lumbar spine specimens.Spine 8 170–180.PubMedGoogle Scholar
  18. 18.
    Fung, BM (1974) Non-freezable water and spin-lattice relation time in muscle containing a growing tumor.Biochimica et Biophysica Acta 362 209–214.PubMedGoogle Scholar
  19. 19.
    Belton, PS, Packer, KJ and Sellwood, TC (1973) Pulsed NMR studies of water in striated muscle. II. Spin-lattice relaxation times and the dynamics of the non-freezing fraction of the water.Biochimica et Biophysica Acta 304 56–64.PubMedGoogle Scholar
  20. 20.
    Woodard, HQ and White, DR (1986) The composition of body tissues.BJR 59 1209–1219.PubMedGoogle Scholar

Copyright information

© Chapman & Hall 1993

Authors and Affiliations

  • marianne Petrén-mallmin
    • 2
  • Anders Ericsson
    • 2
  • Wolfgang Rauschning
    • 1
  • Anders Hemmingsson
    • 2
  1. 1.Departments of Orthopaedic SurgeryUniversity HospitalUppsalaSweden
  2. 2.Department of Diagnostic RadiologyUniversity HospitalUppsalaSweden

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