, Volume 1, Issue 3–4, pp 109–113 | Cite as

A possible role of in-flow effects in functional MR-imaging

  • gregor Gomiscek
  • Roland Beisteiner
  • Karl Hittmair
  • Edgar Mueller
  • Ewald Moser


The potential of functional MR-imaging at 1.5 T was studied using optical stimulation of the human brain. Differences in the image intensity of up to 30% were obtained in the visual cortex area, correlating with the time course of the stimuli. A simplified semi-quantitative model describing the role of in-flow effects in brain vessels on signal increase during the stimulation period is presented.


magnetic resonance blood in-flow effects gradient echo functional imaging visual stimulation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Belliveau JW, Kennedy DN, McKinstry RC, Buchbinder BR, Weiskoff R, Cohen MS, Vevea JM, Brady TJ and Rosen BR (1991)Science 254 716.PubMedGoogle Scholar
  2. 2.
    Turner R, Jezzard P, Wen H, Kwong KK, Le Bihan D, Zeffiro T and Balaban R (1993)Magn Res Med 29 277.Google Scholar
  3. 3.
    Ogawa S, Tank DW, Menon R, Ellermann J, Kim S-G, Merkle H and Ugurbil K (1992)Proc Natl Acad Sci USA 89 5951.PubMedGoogle Scholar
  4. 4.
    Haase A, Frahm J, Matthei D, Hänicke W and Merboldt K-D (1986) FLASH Imaging. Rapid NMR Imaging Using Low Flip-Angle Pulses.J Magn Res 67 258.Google Scholar
  5. 5.
    Frahm J, Haase A and Matthei D (1986)Magn Res Med 3 321.Google Scholar
  6. 6.
    Gao J-H, Holland SK and Gore JC (1988)Med Phys. 15 809.PubMedGoogle Scholar
  7. 7.
    Ogawa S, Menon RS, Tank DW, Kim S-G, Merkle H, Ellermann JM and Ugurbil K (1993)Biophys J 64 803.PubMedGoogle Scholar
  8. 8.
    Frahm J, Merboldt KD and Hänicke W (1993)Mag Res Med 29 139.Google Scholar
  9. 9.
    EEC Concerted Research Project (1988)Magn Res Imag 6 195.Google Scholar
  10. 10.
    Fox PT, Raichle ME, Mintun MA and Dence C (1988)Science 241 462.PubMedGoogle Scholar
  11. 11.
    Guyton AC (ed.) (1991)Textbook of Medical Physiology 8th edn., Philadelphia: W.B. Saunders Company.Google Scholar
  12. 12.
    Thulborn KR, Waterton JC, Matthews M. and Radda GK (1982)BBA 714 265.PubMedGoogle Scholar
  13. 13.
    Brooks RA and Di Chiro G (1987)Med Phys 14 903.PubMedGoogle Scholar
  14. 14.
    Yamaguchi S, Yamakawa T and Niimi H (1992)Int J Microcirc Clin Exp 11 403.PubMedGoogle Scholar
  15. 15.
    Hajnal JV, White SJ, Pennock JM, Oatridge A, Baudouin CJ, Young IR and Bydder GM (1992) Functional imaging of the brain at 1.0T and 0.15T using Fluid Attenuated Inversion Recovery (FLAIR) pulse sequences. Book of Abstracts,Annual Meeting of the SMRM, Berlin, August 8–14, p. 1023.Google Scholar

Copyright information

© Chapman & Hall 1993

Authors and Affiliations

  • gregor Gomiscek
    • 1
    • 2
  • Roland Beisteiner
    • 3
  • Karl Hittmair
    • 2
  • Edgar Mueller
    • 4
  • Ewald Moser
    • 1
    • 2
  1. 1.Arbeitsgruppe NMR, Institut für Medizinische PhysikUniversity of ViennaAustria
  2. 2.MR-InstitutUniversity of ViennaAustria
  3. 3.Neurologische Universitäklinik, University of ViennaAustria
  4. 4.Austria Siemens MedizintechnikErlangenGermany

Personalised recommendations