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Effect of ipriflavone in combination with calcium supplements on bone metabolism in elderly osteoporotic women

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Abstract

Ipriflavone and calcium supplements are used in the treatment of osteoporosis. However, the effect of ipriflavone in combination with high-dose calcium supplements (1 g/day) on bone metabolism in elderly osteoporotic women is still a matter of controversy. Enrolled in this study were 22 women over 70 years of age diagnosed as having involutional osteoporosis. The patients were randomly assigned to treatment with either ipriflavone plus calcium or with calcium supplements only for 6 months. Biochemical markers of bone metabolism and bone mass of the hand were determined at baseline and at 6 months. Serum parathyroid hormone, serum osteocalcin, serum alkaline phosphatase, and the urinary hydroxyproline/creatinine ratio decreased in both groups. These decreases were greater in the “ipriflavone plus calcium supplement” group than in the “calcium supplement only” group. Serum calcitonin increased in the “ipriflavone plus calcium supplement” group. Metacarpal index and metacarpal bone mineral density did not change in either group. These findings suggest that treatment with ipriflavone plus calcium supplements may inhibit bone resorption and modulate bone turnover in elderly osteoporotic women and may be more effective than calcium supplements alone.

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Author notes

  1. Kiyoshi Aoyagi

    Present address: Department of Orthopaedic Surgery, Mitsugi Public General Hospital, 124 Ichi, Mitsugi, Mitsugi-gun, 722-01, Hiroshima, Japan

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Mitsugi Public General Hospital, 124 Ichi, Mitsugi, Mitsugi-gun, 722-01, Hiroshima, Japan

    Takuo Hayashi, Hiroshi Inoue & Kazuhiro Takahara

  2. Department of Orthopaedic Surgery, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, 852, Nagasaki, Japan

    Katsuro Iwasaki

  3. Department of Orthopaedic Surgery, Nagasaki Rosai Hospital, 2-12-5 Setogoshi, Sasebo, 857-01, Nagasaki, Japan

    Kazuhiro Yamaguchi

Authors
  1. Kiyoshi Aoyagi
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  2. Katsuro Iwasaki
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  3. Takuo Hayashi
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  4. Hiroshi Inoue
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  5. Kazuhiro Yamaguchi
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  6. Kazuhiro Takahara
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Aoyagi, K., Iwasaki, K., Hayashi, T. et al. Effect of ipriflavone in combination with calcium supplements on bone metabolism in elderly osteoporotic women. J Bone Miner Metab 14, 79–82 (1996). https://doi.org/10.1007/BF01768836

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  • DOI: https://doi.org/10.1007/BF01768836

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