Journal of Bone and Mineral Metabolism

, Volume 14, Issue 2, pp 73–78 | Cite as

Effect of elcatonin on involutional osteoporosis

  • Hajime Orimo
  • Hirotoshi Morii
  • Tetsuo Inoue
  • Kichizo Yamamoto
  • Hiroshi Minaguchi
  • Yoshiaki Ishii
  • Kagehisa Murota
  • Etsuo Fujimaki
  • Ryo Watanabe
  • Seiko Harata
  • Hideo Honjo
  • Takuo Fujita
Original Articles


A total of 127 patients with involutional osteoporosis were randomly divided into two groups. The elcatonin group consisted of 67 patients who received 20 units of elcatonin per week administered intramuscularly, together with 0.6g calcium lactate (100mg as calcium) given orally three times daily for 24 weeks. The other 60 patients were assigned to a control group receiving 0.6g calcium lactate orally three times daily. Forty patients were withdrawn from the study treatment or dropped out during the study. The other 87 patients (consisting of 45 in the elcatonin group, and 42 in the control group) were measured for lumbar vertebral bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA). The BMD was increased significantly (P < 0.05) by 1.87 ± 0.79% (mean ± standard error) in the elcatonin group and decreased by 0.61 ± 0.93% in the control group at the end of the study. The difference between the two groups was statistically significant (P < 0.05). The results of the present study demonstrated that elcatonin increases the BMD in patients with involutional osteoporosis.

Key words

calcitonin-elcatonin DXA bone mineral density osteoporosis 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Hajime Orimo
    • 1
  • Hirotoshi Morii
    • 2
  • Tetsuo Inoue
    • 3
  • Kichizo Yamamoto
    • 4
  • Hiroshi Minaguchi
    • 5
  • Yoshiaki Ishii
    • 6
  • Kagehisa Murota
    • 7
  • Etsuo Fujimaki
    • 8
  • Ryo Watanabe
    • 9
  • Seiko Harata
    • 10
  • Hideo Honjo
    • 11
  • Takuo Fujita
    • 12
  1. 1.Department of GeriatricsUniversity of Tokyo School of MedicineTokyoJapan
  2. 2.Second Department of Internal MedicineOsaka City University School of MedicineOsakaJapan
  3. 3.Department of Orthopedic SurgeryHamamatsu University School of MedicineShizuokaJapan
  4. 4.Department of Orthopedic SurgeryTottori University School of MedicineTottoriJapan
  5. 5.Department of Obstetrics and GynecologyYokohama City University School of MedicineYokohamaJapan
  6. 6.Department of Orthopedic SurgeryKyorin University School of MedicineTokyoJapan
  7. 7.Department of Orthopedic SurgeryJikei University School of MedicineTokyoJapan
  8. 8.Department of Orthopedic SurgeryShowa University School of MedicineTokyoJapan
  9. 9.Department of Orthopedic SurgeryKawasaki Medical SchoolOkayamaJapan
  10. 10.Department of Orthopedic SurgeryHirosaki University School of MedicineAomoriJapan
  11. 11.Department of Obstetrics and GynecologyKyoto Prefectural University School of MedicineKyotoJapan
  12. 12.Third Department of Internal MedicineKobe University School of MedicineHyogoJapan

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